专利号:US-10000432-B2 优先权日:2014-01-13 标 题 :Processes for the synthesis of chiral 1-alkanols 发明人:NEGISHI EI-ICHI 权利人:PURDUE RESEARCH FOUNDATION 摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
专利号:EP-3094613-A1 优先权日:2014-01-13 标题:Processes for the synthesis of chiral 1-alkanols
专利号:US-2016332940-A1 优先权日:2014-01-13 标 题:Processes for the synthesis of chiral 1-alkanols
专利号:WO-2015106045-A1 优先权日:2014-01-13 标 题:Processes for the synthesis of chiral 1-alkanols
专利号:US-2008139663-A1 优先权日:2006-09-15 标 题 :Synthesis, methods of using, and compositions of cycloalkylmethylamines
专利号:US-9868718-B2 优先权日:2006-01-06 标 题 :Cycloalkylamines as monoamine reuptake inhibitors 发明人:SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E 权利人:SUNOVION PHARMACEUTICALS INC 摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.