CAS: 40851-66-9; 2-(Boc-Aminomethyl)Phenylacetic Acid

上下游产品

CAS号147410-31-9 METHYL 2-(2-((T... | CAS号18698-97-0 邻溴苯乙酸 | CAS号57486-69-8 2-(2-溴苯基)乙酸甲酯 | CAS号20921-96-4 (2-氰基苯基)乙酸甲酯 | CAS号749832-15-3 methyl 2-(2-(am... | CAS号124-38-9 二氧化碳 | CAS号138350-83-1 N-[(2-甲基苯基)甲基]氨... | CAS号24331-94-0 1,4-二氢-3(2h)-异喹啉酮

📜(2-氰基苯基)乙酸甲酯置于palladium On Activated Charcoal 盐酸,Lithium Hydroxide,氢气,三乙胺体系中,用 四氢呋喃,甲醇 作为反应溶剂,25.0 °C,482.63 Kpa 条件下,反应生成 Boc-2-氨甲基苯乙酸
参考文献:Arylacetamide K Opioid Receptor Agonists With Reduced Cytochrome P450 2D6 Inhibitory Activity
标题:Arylacetamide K Opioid Receptor Agonists With Reduced Cytochrome P450 2D6 Inhibitory Activity
摘要:Some K Opioid Receptor Agonists Of The Arylacetamide Class,For Example,Ici 199441 (1),Were Found To Strongly Inhibit The Activity Of Cytochrome P450 2D6 (Cyp2D6) (1: Cyp2D6 Ic50 = 26 Nm). Certain Analogs Bearing A Substituted Sulfonylamino Group,For Example,13,Were Discovered To Have Significantly Reduced Cyp2D6 Inhibitory Activity (13: Cyp2D6 Ic50 > 10 Mu M) While Displaying High Affinity Toward The Cloned Human K Opioid Receptor,Good Kappa/delta And Kappa/mu Selectivity,And Potent In Vitro And In Vivo Agonist Activity. (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2005.03.020

专利信息

专利号:JP-S5934197-B2
优先权日:1972-08-30
标题 :Synthesis of antibacterial agent intermediates

专利号:JP-S5823378-B2
优先权日:1972-08-30
标题:Synthesis of antibacterial agent intermediates