CAS: 36889-13-1; L-Nio

该化合物是氨基酸L-onithine的经修改衍生物,在N5位置上有一个非硝基乙基组,这种结构改变加强了其在生化途径中作为前体的作用,特别是在对细胞信号和扩散至关重要的氮氧化物和多聚胺合成中.复合物的显示改善了稳定性和生物利用率,而不是未经过修改的L-onithine,使其在新陈代谢研究,酶抑制和心血管或免疫系统调查等研究应用中具有价值.其特性和再活性也使其在生动丙烷酶和氮氧化合成酶活动中有用,为相关的生理和病理过程提供见解.

结构式图片

相似化合物

157-06-2 7200-25-1 74-79-3

MSDS等安全信息

合成工艺路线路线简述

    📜乙基乙酰亚胺盐酸盐,L-鸟氨酸盐酸盐 反应生成 L-N5-(1-亚胺乙基)-鸟氨酸盐酸盐
    参考文献:Antimetabolites Produced By Microorganisms. Vi 1) L-N5-(1-Iminoethyl) Ornithine
    标题:Antimetabolites Produced By Microorganisms. Vi 1) L-N5-(1-Iminoethyl) Ornithine
    摘要:从一种未分类的链霉菌产生的发酵液中分离出一种新的精氨酸抗代谢物和代谢相关化合物. 该结构被证明是l-N5-(1-亚氨基乙基)鸟氨酸,该化合物是通过l-鸟氨酸铜络合物与乙酰亚胺乙酯的反应合成的. 该化合物的弱碱水解产生了预期的产物l-鸟氨酸和l-N5-乙酰鸟氨酸,此外还有一种重排产物l-N2-乙酰鸟氨酸. 精氨酸酶将抗代谢物水解为l-鸟氨酸.
    DOI:10.7164/antibiotics.25.179

    海关参考信息

    专利信息


    专利号:US-5795574-A
    优先权日:1995-09-07
    标题:Use of an extract from a non-photosynthetic filamentous bacterium and composition containing it
    发明人:BRETON LIONEL; AUBERT LUCIEN; LECLAIRE JACQUES; MARTIN RICHARD; DE LACHARRIERE OLIVIER
    权利人:OREAL
    摘要:The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the preparation of a pharmaceutical composition. The invention also relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium in a cosmetic composition or for the preparation of a pharmaceutical composition intended for the treatment of disorders associated with an excess in the synthesis and/or in the release of substance P. The invention additionally relates to various compositions containing an extract from at least one non-photosynthetic filamentous bacterium and to a cosmetic treatment process.

    专利号:US-5449688-A
    优先权日:1993-03-30
    标 题:Method of treating chronic inflammatory diseases
    发明人:WAHL SHARON M; ALLEN JANICE B; MCCARTNEY-FRANCIS NANCY L
    权利人:US ARMY
    摘要:The present invention provides a method for treating chronic inflammatory conditions, including autoimmune diseases by administering an effective amount of an agent, such as a nitric oxide synthase inhibitor, a nitric oxide scavenger, or an inhibitor of tetrahydrobiopterin synthesis, to decrease the amount of nitric oxide present at the site of inflammation.

    专利号:CN-117101715-A
    优先权日:2023-10-08
    标题:Amine modified bimetallic supported catalyst, preparation method and application thereof in grease synthesis of aviation oil

    专利号:US-6146636-A
    优先权日:1997-09-22
    标题 :Substance P antagonists comprising rosaceae plant extracts
    发明人:BRETON LIONEL; PINEAU NATHALIE
    权利人:OREAL
    摘要:Disease states, disorders, conditions or afflictions manifesting excessive synthesis and/or release of substance P are therapeutically treating by administering to individuals in need of such treatment, an effective substance P antagonist amount of at least one extract of at least one plant of the Rosaceae family.

    专利号:RU-2193554-C2
    优先权日:1996-12-24
    标题 :DERIVATIVES OF AROMATIC AMINES ELICITING EFFECT INHIBITING OAC, METHOD OF THEIR SYNTHESIS AND INHIBITOR OF нOAC

    专利号:WO-2007056389-A2
    优先权日:2005-11-07
    标题 :Synthesis and use of novel inhibitors and inactivators of protein arginine deiminases

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Muzaffar S, Jeremy JY, Angelini GD, Stuart-Smith K, Shukla N. Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries. Thorax. 2003 Jul;58(7):598-604.
    2: Conant K, Ahmed U, Schwartz JP, Major EO. IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric oxide dependent mechanism. J Neuroimmunol. 1998 Aug 1;88(1-2):39-44.

    合成参考文献


    参考文献:10.1007/s10571-008-9272-3
    摘要:Curto-Reyes V, Juárez L, García-Pérez E, Fresno MF, Hidalgo A, Menéndez L, Baamonde A. Local Loperamide Inhibits Thermal Hyperalgesia But Not Mechanical Allodynia Induced by Intratibial Inoculation of Melanoma Cells in Mice. Cellular and Molecular Neurobiology. 2008 Mar 22;28(7):981–90. doi: 10.1007/s10571-008-9272-3.
    参考文献:10.1021/jm00049a007
    摘要:Moore WM, Webber RK, Jerome GM, Tjoeng FS, Misko TP, Currie MG. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886–8. doi: 10.1021/jm00049a007.
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