专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-11414365-B2 优先权日:2018-01-30 标题:Natural 1,2-alkanediols, compositions having natural 1,2-alkanediols and processes for making the same 发明人:BURGO ROCCO V; WRIGHT MICHAEL E; MOSSER GARY B; FEVOLA MICHAEL J 权利人:INOLEX INVESTMENT CORP 摘要:A process is incorporated herein for the synthesis of bio-1,2-alkanediols, comprising: providing a bio-alkene having a carbon chain of about 5 to about 20 carbon atoms and a bio-1-alkene regioselectivity of at least about 80%, at least about 92% and/or at least about 95%; and converting the bio-alkene to a bio-1,2-alkanediol having a carbon chain length of about 5 to about 20 carbon atoms. Methods for treating catalysts which may be incorporated in the process for the synthesis of bio-1,2-alkanediols are also included herein. Such bio-1,2-alkanediols are used in compositions and products alone as antimicrobial materials, or with existing bio-compounds and/or antimicrobials, preservatives, alternative preservation systems and/or hurdle technology components. The bio-1,2-alkanediols incorporate a natural and bio-based pathway for antimicrobial effects in various compositions such as cosmetic, pharmaceutical, industrial and household products.
专利号:US-9314021-B2 优先权日:2004-11-03 标题 :Formulations containing insect repellent compounds 发明人:SCIALDONE MARK A 权利人:DU PONT 摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, and compositions thereof, which also has fragrance properties, may be used commercially for its insect repellent properties.
专利号:US-2016128578-A1 优先权日:2014-11-06 标题 :System And Method For Synthesis Of Impedance Matching And Signal Converting Material For All Optical Photo-Acoustic Detection
专利号:US-3873597-A 优先权日:1971-04-05 标 题 :2-Bromo-2-bromomethylglutaronitrile 发明人:HARMETZ RONALD; TULL ROGER J 权利人:MERCK & CO INC 摘要:In the synthesis of 3-cyanopyridine from non-heterocyclic starting materials, namely, 2-methyleneglutaronitrile the intermediate 2-bromo-2-bromomethylglutaronitrile is obtained, which intermediate compound is useful as an antibacterial and antifungal agent.
专利号:US-6221371-B1 优先权日:1996-11-11 标题:Pseudoceramides, and dermatologic external preparations containing the same 发明人:BAIK IN-SUB; LEE JONG-GI; PARK BYEONG-DEOG; KIM YOON; LEE MYUNG-JIN 权利人:AEKYUNG IND CO INC 摘要:The present invention relates to pseudoceramide derivatives represented by formula(I) or (II):wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6~22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2~C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
[参考文献]: Angela E Aakhus, Et Al. Allergy To Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400): Regulatory Issues, Epidemiology, Clinical Characteristics, And Management. Dermatitis. 2011 May;22(3):127-40. [参考文献]: Cecilia Svedman, Et Al. Follow-Up Of The Monitored Levels Of Preservative Sensitivity In Europe: Overview Of The Years 2001-2008. Contact Dermatitis. 2012 Nov;67(5):312-4. [参考文献]: Huijun Liu, Et Al. Determination Of Bromothalonil Residues And Degradation In Apple And Soil By Quechers And Gc-Ms/ms. Bull Environ Contam Toxicol. 2014 Apr;92(4):451-4. [参考文献]: Ian R Jowsey, Et Al. Proliferative Responses In The Local Lymph Node Assay Associated With Concomitant Exposure To 1,4-Phenylenediamine And Methyldibromo Glutaronitrile: Evidence For Synergy. Contact Dermatitis. 2008 Aug;59(2):90-5. [参考文献]: Jacob P Thyssen, Et Al. Temporal Trends Of Preservative Allergy In Denmark (1985-2008). Contact Dermatitis. 2010 Feb;62(2):102-8.
合成参考文献
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