CAS: 354-23-4; 1,2-Dichloro-1,1,2-Trifluoroethane

该化合物是一种卤化有机化合物,是一种无色,不易燃的液体,有甜味,较容易在受控制环境中处理,其特性是分子结构,包括两个氯原子和三氟原子,附于一个双碳乙烷主干柱,有助于其化学稳定性和低再活性;它有一个中度沸点,水溶性较低,同时在有机溶剂中更易溶解;由于其卤化性质,它受到检查,以了解其潜在的环境影响,特别是臭氧消耗和全球升温潜能;安全考虑包括它可能造成呼吸刺激和接触时的其他健康影响;随着制冷剂条例的演变,在许多区域,使用1,1,1,2-三氟乙烷受到限制,促使转向更环保的替代品.

结构式图片

上下游产品

1,1,2-trichloro-2,2-difluoroethane 1,2,2-trichloro-1,2-difluoroethane 1,2-dibromo-1,1,2-trichloroethane 1,2-dichloro-1,2,2-trifluoro-1-iodoethane Chlorotrifluoroethylene 1,1,2-trifluoroethylene 1,1,1-trifluoro-2,2-dichloroethane cis-1,2-dichloro-1,2-difluoroethene

合成工艺路线路线简述

    📜1,2-二溴-1,1,2-三氯乙烷置于氢氟酸,氯化锑(V)体系中,化学反应生成1,2-二氯三氟乙烷
    参考文献:Manufacture Of Trifluorochloroethylene
    标题:Manufacture Of Trifluorochloroethylene

    海关参考信息

    专利信息


    专利号:US-2008032964-A1
    优先权日:2006-04-10
    标题:Process for the synthesis of azetidinone
    发明人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

    专利号:US-9126995-B2
    优先权日:2011-11-08
    标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
    发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
    权利人:NISSAN CHEMICAL IND LTD
    摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

    专利号:US-8128902-B2
    优先权日:2011-04-12
    标题:Method for the synthesis of anhydrous hydrogen halide and anhydrous carbon dioxide
    发明人:TARANCON III GREGORIO
    权利人:TARANCON III GREGORIO; MIDWEST REFRIGERANTS LLC
    摘要:A method for the synthesis of anhydrous hydrogen halide fluids from organic halide fluids, such as perfluorocarbon fluids and refrigerant fluids, and anhydrous carbon dioxide for the environmentally safe disposition thereof.

    专利号:US-8084630-B2
    优先权日:2007-05-31
    标 题 :Process for the synthesis of ramelteon and its intermediates
    发明人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
    权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
    摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

    专利号:US-2009081801-A1
    优先权日:2007-08-15
    标题:Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
    发明人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
    权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
    摘要:The present invention also relates to a novel impurity, (6-{2-[2-(6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetylamino]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetic acid tert-butyl ester, the compound of formula IV, having the following structure: n n n n n n n n n n The present invention also provides methods of preparing the compound of formula IV as well as methods of using the compound of formula IV as a reference marker and a reference standard. n The present invention also provides an improved process for preparing (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester, the compound of formula I, said process comprising the step of condensing 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butanamide, the compound of formula III, with (4R,Cis)-1,1-dimethylethyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound of formula II, in the presence of a catalytic amount of an acid in the presence of a solvent system, preferably a binary solvent system, to obtain the desired compound (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester.

    专利号:US-7319175-B2
    优先权日:2001-12-21
    标 题 :Catalyst synthesis of halogenated compounds with catalyst regeneration with elemental halogen
    发明人:BRAUN MAX; BROSCH CARSTEN
    权利人:SOLVAY FLUOR & DERIVATE
    摘要:Catalysts such as antimony halides, which are useful in fluorination reactions involving hydrogen fluoride, may be reduced during the reaction and require regeneration. Regenerative oxidation is usually carried out by introducing elemental halogen, preferably fluorine or chlorine, into the reaction mixture. In accordance with the invention elemental halogen is prevented from coming into contact with starting materials or intermediate products which are reactive therewith. This is preferably achieved by withdrawing part of the reaction mixture from the reactor, mixing the withdrawn part with chlorine or fluorine in order to regenerate the catalyst, and thereafter returning the withdrawn part to the reactor.

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    合成参考文献


    摘要:Anaesthesia., 16(3), 1961 []
    摘要:USEPA/Atmospheric Research & Exposure Assessment Laboratory (AREAL); Compendium of Methods for the Determination of Air Pollutants in Indoor Air, Engineering Science, One Harrison Park, Suite 305, 401 Harrison Oaks Blvd, Cary, NC 27513 as cited in USEPA; EMMI. Environmental Monitoring Index Database Version 1.02 (1992) EPA/871-B-92-001 (NTIS Document No. PB92-503093)
    摘要:Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 222
    摘要:Smart BE, Fernandez RE; Kirk-Othmer Encyclopedia of Chemical Technology. (1999-2012). New York, NY: John Wiley & Sons; Fluorinated Aliphatic Compounds. Online Posting Date: December 4, 2000.
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
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