CAS: 35388-57-9; (2R,3S)-2,3-Dihydroxy-2-(4-Hydroxybenzyl)Succinic Acid

相似化合物

306-23-0 23508-35-2 3972-36-9

上下游产品

Dimethyl (2R,3S)-2,3-Dihydroxy-2-(4-Hydroxybenzyl)Succinate 51705-36-3
Dimethyl (2S,3R)-2-(4-Tert-Butyldimethylsilyloxybenzyl)Tartrate 240405-27-0

📜4-苄氧基溴苄置于palladium 10% On Activated Carbon,水,氢气,三氟乙酸,Potassium Hydroxide,Lithium Diisopropyl Amide体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,水,乙酸乙酯 用作溶剂,-78.0~20.0 °C,344.75 Kpa 条件下,反应 21.25H,反应生成2,3-二羟基-2-[(4-羟基苯基)甲基]丁二酸
参考文献:(+)-鱼腥草酸和升麻酸l的立体选择性合成
标题:(+)-鱼腥草酸和升麻酸l的立体选择性合成
摘要:使用 4-苄氧基苄基溴对 (2S,3S,5S,6S)-二甲氧基-2,3-二甲基-1,4-二氧六环-5,6-二硫代羧酸锂的烯醇化锂进行立体选择性的烷基化,得到两个带有羧酸根的新立体中心在顺式关系中.该中间体的水解脱保护产生天然产物 (+)-鱼腥草酸.在仲羟基上安装肉桂酸酯,然后选择性脱保护,得到比例为 3:1 的顺式/反式肉桂酸酯混合物.最终得到天然产物升麻酸l.
Doi:10.1002/ejoc.201501002

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.