CAS: 328-38-1; H-D-Leu-Oh

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328-39-2 61-90-5 114360-54-2

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CAS号24292-07-7 D-α-Hydrazino-i... | CAS号161633-97-2 (R)-benzyl 4-me... | CAS号328-39-2 (±)-氨基-4-甲基戊酸 | CAS号170642-24-7 (R)-2-amino-N-(... | CAS号89384-51-0 (S)-2-(苄基氨基)-4-甲基戊酸 | CAS号113543-42-3 (3(2R),4S)-3-(2... | CAS号19892-92-3 (R)-2-羟基-4-甲基戊酸叔丁酯 | CAS号816-66-0 4-甲基-2-氧戊酸 | CAS号6893-26-1 D-谷氨酸 | CAS号28659-87-2 (S)-2-溴-4-甲基戊酸 | CAS号328-39-2 (±)-氨基-4-甲基戊酸 | CAS号19764-30-8 N-乙酰-D-亮氨酸 | CAS号100-02-7 对硝基苯酚 | CAS号28862-79-5 CBZ-D-亮氨酸 | CAS号688-13-1 甘铵酰亮胺基乙酸 | CAS号5845-53-4 D-亮氨酸甲酯盐酸盐

4-甲基-2-氧代戊酸置于d-丙氨酸,Meso-Diaminopimelate Dehydrogenase,磷酸吡哆醛,Alcohol Dehydrogenases From Bacillus Stearothermophilus,Alcohol Dehydrogenases From Thermoanaerobacter Brockii,还原型辅酶ⅰ体系中,用 异丙醇 作为反应溶剂,化学反应 12.0H,以53.2%的收率获得产物d-亮氨酸
参考文献:一锅中含三种酶的人工生物催化级联反应,用于不对称合成手性非天然氨基酸
标题:一锅中含三种酶的人工生物催化级联反应,用于不对称合成手性非天然氨基酸
摘要:开发了一种人工生物催化级联,用于光学纯非天然氨基酸的不对称合成.该方法在一锅反应中使用了三种酶,酶组合具有很大的灵活性,具有较宽的底物谱.仅使用催化量的氨基供体,该反应就可以达到完全转化,并且d和l产物的纯度都很高.
DOI:10.1002/ejoc.201900828

专利信息

专利号:US-6350595-B1
优先权日:1997-10-28
标题:Synthesis of polynucleotides having random sequences
发明人：NEUNER PHILIPPE
权利人:ISTITUTO DI RICERCHE DI MOLECO
摘要:Subject of this invention is a process for the chemical synthesis of polynucleotides having totally or partially random sequences, based on the utilization, as synthesis monomer units for the random sequence part, or presynthesized mononucleotides and dinucleotides. Said synthesis is carried out on separate supports, so that on each of those supports is alternated at least one reaction cycle wherein a mixture of said dinucleotides is bound, with at least one reaction cycle wherein a mononucleotide is bound, and that in a preferred embodiment at the end of the n cycles required for a codon synthesis, the supports are mixed and then redivided into one or more reaction containers. The resulting polynucleotides are such that, for the random sequence part, each trinucleotide unit is fit to match only a limited number of codons, predefined for each unity in number and sequence, and the genetic code degeneracy effects can thus be eliminated. FIG. 1 shows the chemical structure of the dinucleotides utilized as monomer units for the synthesis of codons forming the final sequence.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-2024035023-A1
优先权日:2022-06-24
标题 :Computer implemented method for engineering fluorinase enzymes for synthesis of fluorophenyl compounds
发明人：R PRAVIN KUMAR; G GLADSTONE SIGAMANI; L ROOPA; B K NAVEEN; SHETTY ANUJ J; M LIKITH
权利人:KCAT ENZYMATIC PRIVATE LTD
摘要:The present invention discloses a computer-implemented method for engineering fluorinase enzymes towards the synthesis of fluorophenyl compounds. Limited or no mechanistic details of fluorinase enzymes have hindered progress in understanding their catalytic mechanisms for synthesizing synthetic organofluorine compounds. Through a comprehensive computational screening process, specific methionine-sulfonium phenyl substrates, including [(3S)-3-amino-3-carboxypropyl][2,5-difluoro-4-(4-methoxy-2,4-dioxobutyl)phenyl]methylsulfonium, were designed and optimized using quantum chemical optimization techniques. This methodology uncovers crucial information on F— ion attack conformation and the catalytic mechanism of the substrate, leading to the formation of Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate. Furthermore, a protein sequence and 3D modeling-based enzyme screening process was employed to identify the most suitable enzyme for this substrate. The identified enzyme was then engineered using the mechanistic insights gained from the studies, resulting in improved substrate scope, stability and catalytic efficiency. This computer-based approach offers an efficient and precise alternative to traditional trial-and-error methods, advancing the field towards the successful synthesis fluorophenyl compounds.

专利号:US-2024287126-A1
优先权日:2021-05-14
标 题:Novel synthesis of cholesterol
发明人：SCHINZER DIETER; SPIESS OLIVER; MUNT MAXIM; INDOLESE ADRIANO; ROUX LIONEL
权利人:CORDENPHARMA INT GMBH; UNIV OTTO VON GUERICKE MAGDEBURG; CORDENPHARMA INT
摘要:The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.

专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-2010279334-A1
优先权日:2007-10-31
标题 :Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides
发明人：SAUGUET LUDOVIC; THAI ROBERT; BELIN PASCAL; LECOQ ALAIN; GENET ROGER; PERNODET JEAN-LUC; GONDRY MURIEL
权利人:KYOWA HAKKO BIO CO LTD; CENTRE NAT RECH SCIENT; UNIV PARIS SUD 11; COMMISSARIAT ENERGIE ATOMIQUE
摘要:Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides.