CAS: 20736-08-7; (2S,3R,4R,5R,6S)-2-(((2R,3S,4R,5R,6R)-4,5-Dihydroxy-6-(((3S,4Ar,6Ar,6Bs,8S,8As,12Ar,12Bs,14Ar,14Bs)-8-Hydroxy-4,4,6A,6B,11,11,14B-Heptamethyl-2,3,4,4A,5,6,6A,6B,7,8,10,11,12,12A,14A,14B-Hexadecahydro-1H,9H-12B,8A-(Epoxymethano)Picen-3-yl)Oxy)-2-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol
该化合物是主要源于布普勒姆法尔卡图姆植物根部的三叶虫素沙邦素,以其在传统医学中的使用而著称;该化合物的特点是结构复杂,包括类固醇骨和糖糖,有助于其生物活动;Saikosaponin C展示了一系列药理特性,包括抗炎,肝保护,免疫疗法效应;研究其在治疗肝病和某些癌症等各种条件方面的潜力;该化合物通常溶于有机溶剂,显示水中的溶性有限,这是鲑鱼的一个常见特征;其行动机制往往涉及信号路径的调节和与细胞膜的相互作用;由于其生物活性性质,Saikosaponin C对药理学研究和潜在治疗应用都感兴趣,尽管需要进一步研究以充分阐明其对人类的影响和安全性.
- 英文名称(2S,3R,4R,5R,6S)-2-(((2R,3S,4R,5R,6R)-4,5-Dihydroxy-6-(((3S,4Ar,6Ar,6Bs,8S,8As,12Ar,12Bs,14Ar,14Bs)-8-Hydroxy-4,4,6A,6B,11,11,14B-Heptamethyl-2,3,4,4A,5,6,6A,6B,7,8,10,11,12,12A,14A,14B-Hexadecahydro-1H,9H-12B,8A-(Epoxymethano)Picen-3-yl)Oxy)-2-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称柴胡皂苷C
- IUPAC名称(2S,3R,4R,5R,6S)-2-(((2R,3S,4R,5R,6R)-4,5-dihydroxy-6-(((3S,4aR,6aR,6bS,8S,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-2,3,4,4a,5,6,6a,6b,7,8,10,11,12,12a,14a,14b-hexadecahydro-1H,9H-12b,8a-(epoxymethano)picen-3-yl)oxy)-2-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
- 其它别名Saikosaponin C; Saikosaponian C; Saikosaponin C(P); (3Beta,4Alpha,16Beta)-13,28-Epoxy-16,23-Dihydroxyolean-11-En-3-Yl O-6-Deoxy-Alpha-L-Mannopyranosyl-(1-4)-O-Beta-D-Glucopyranosyl-(1-6)-Beta-D-Glucopyranoside; Chikusakoside Ii; B-D-Glucopyranoside, (3B,16B)-13,28-Epoxy-16-Hydroxyolean-11-En-3-Yl O-6-Deoxy-A-L-Mannopyranosyl-(14)-O-[b-D-Glucopyranosyl-(16)]-; [13,28-Epoxy-16β-Hydroxyolean-11-En-3β-Yl]4-O-(6-Deoxy-α-L-Mannopyranosyl)-6-O-(β-D-Glucopyranosyl)-β-D-Glucopyranoside
- CAS编号20736-08-7
- MFCD编号:MFCD00075673
- EINECS号:633-797-4
- 分子式:C48H78O17分子量:927.14
- 产品CID: 1056648
- 产品分类生物化工 → 提取物
物理性质
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海关参考信息
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2901220000-丙烯
2905122000-异丙醇
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主要参考文献
1: Chen X, Wu H, Li P, Peng W, Wang Y, Zhang X, Zhang A, Li J, Meng F, Wang W, Su W. Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast- Induced Fever Based on Network Analysis and Experimental Validation. Pharmaceuticals (Basel). 2024 Apr 8;17(4):475. doi: 10.3390/ph17040475.
2: Chen S, Wang K, Wang H, Gao Y, Nie K, Jiang X, Su H, Tang Y, Lu F, Dong H, Wang Z. The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications. Pharmacol Res. 2024 Mar;201:107090. doi: 10.1016/j.phrs.2024.107090. Epub 2024 Feb 1. 37(6):e23339. doi: 10.1002/jbt.23339. Epub 2023 Apr 3.
118:110043. doi: 10.1016/j.intimp.2023.110043. Epub 2023 Mar 23.
合成参考文献
参考文献:10.1271/bbb.65.1648
摘要:KIM N, PARK I. Purification of Saponin Compounds in Bupleurum falcatum by Solvent Partitioning and Preparative LC. Bioscience, Biotechnology, and Biochemistry. 2001 Jan;65(7):1648–51. doi: 10.1271/bbb.65.1648.
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