CAS: 179552-73-9; 7-Chloro-N-(3-Chloro-4-Fluorophenyl)-6-Nitroquinazolin-4-Amine

上下游产品

4-(3-chloro-4-fluoroanilino)-6-isothi°Cyanato-7-methoxyquinazoline hydr°Chloride salt 3-chloro-4-fluorophenylamine H-quinazolin-4-one7-chloro-8-nitro-3H-quinazolin-4-one 7-chloro-6-nitro-4(3H)-quinazolinone N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin- 4-amine N-((3-chloro-4-fluorophenyl)-6-nitro-7-phenylsulfonyl)quinazolin-4-one 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

2-氨基-4-氯苯甲酸置于硫酸,硝酸,三乙胺,三氯氧磷体系中,用 1,4-二氧六环,水,乙腈 用作溶剂,化学反应 1.0H,反应生成7-氯-N-(3-氯-4-氟苯基)-6-硝基-4-氨基喹唑啉
参考文献:新型青蒿素衍生物及其制法和应用
标题:新型青蒿素衍生物及其制法和应用
摘要:本发明涉及新型青蒿素衍生物及其制法和应用.具体地,本发明公开了一类结构如式i所示的青蒿素衍生物或其药学上可接受的盐,或其对映异构体,非对映异构体或外消旋体,其中x,Y,Z,N,K,P如本文中定义.本发明还公开了所述化合物的制法及其应用,所述化合物对治疗肿瘤有优异的效果.

专利信息

专利号:US-8188274-B2
优先权日:2006-01-26
标题 :Process for preparing aminocrotonylamino-substituted quinazoline derivatives
发明人：SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA
权利人:SCHROEDER JUERGEN; DZIEWAS GEORG; FACHINGER THOMAS; JAEGER BURKHARD; REICHEL CARTSEN; RENNER SVENJA; BOEHRINGER INGELHEIM INT
摘要:The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) n nwherein the groups R a , R b , R c and R d have the meanings given in the claims, as well as sulphonyl derivatives of formulan n nand the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.