CAS: 1270084-92-8; 3-Phenyl-4-Propyl-1-(Pyridin-2-yl)-1H-Pyrazol-5-Ol

该化合物是一种针对NADPH氧化酶(NOX)异形,特别是NOX1/4的强大和选择性的小分子抑制剂,其行动机制包括通过蒸发活性氧物种减少氧化压力,使其成为研究炎症,纤维化和...

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    📜2-苯甲酰基戊酸乙酯,2-肼吡啶 以82的收率获得化合物apx-115Freebase
    参考文献:Pyrazole Derivatives,Preparation Method Thereof,And Composition For Preventing And Treating Osteoporosis Containing Same
    标题:Pyrazole Derivatives,Preparation Method Thereof,And Composition For Preventing And Treating Osteoporosis Containing Same
    摘要:本发明提供了一种吡唑衍生物化合物及其药学上可接受的盐.该发明的化合物对于预防和治疗骨质疏松症非常有效.

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    主要参考文献


    1: Lee ES, Kim HM, Lee SH, Ha KB, Bae YS, Lee SJ, Moon SH, Lee EY, Lee JH, Chung CH. APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice. Free Radic Biol Med. 2020 Oct 2;161:92-101. doi: 10.1016/j.freeradbiomed.2020.09.024. Epub ahead of print. 33(5):332-353. doi: 10.1089/ars.2019.7915. Epub 2020 Jan 23. 102(3-4):180-189. doi: 10.1159/000491398. Epub 2018 Aug 10. 8(43):74217-74232. doi: 10.18632/oncotarget.18540.
    5: Cha JJ, Min HS, Kim KT, Kim JE, Ghee JY, Kim HW, Lee JE, Han JY, Lee G, Ha HJ, Bae YS, Lee SR, Moon SH, Lee SC, Kim G, Kang YS, Cha DR. APX-115, a first- in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. doi: 10.1038/labinvest.2017.2. Epub 2017 Feb 6.

    合成参考文献


    参考文献:10.1038/labinvest.2017.2
    摘要:Cha JJ, Min HS, Kim KT, Kim JE, Ghee JY, Kim HW, Lee JE, Han JY, Lee G, Ha HJ, Bae YS, Lee SR, Moon SH, Lee SC, Kim G, Kang YS, Cha DR. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Laboratory Investigation. 2017 Feb 06;97(4):419–31. doi: 10.1038/labinvest.2017.2.
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