CAS: 1091-85-6; 2-(5-(Dimethylamino)Naphthalene-1-Sulfonamido)Acetic Acid

该化合物是一种化学化合物,其特点是其独特的结构,包括附于甘蓝的氨基酸,一种氨基酸,一种配以甘油的双辛基磺酰胺(一种荧光磺酰胺),由于其荧光特性,常常用于生物化学和分析应用,因此对跟踪和检测生物分子很有价值;该化合物一般是白色的白色,对非白色固体而言,在水和乙醇等极地溶剂中可溶解;丹锡甘油在紫外光下表现出很强的荧光,在各种检测和成像技术中非常有用;它与蛋白质和其他生物分子形成稳定的复合体的能力,增强了其在涉及蛋白相互作用和相容变化的研究中的效用;此外,由于该丁锡化合物的结构特征,可以作为pH指标,使研究人员能够监测环境的变化.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号605-65-2 丹酰氯 | CAS号56-40-6 甘氨酸 | CAS号1251073-47-8 N-dansyl-glycin... | CAS号143744-88-1 Dansyl-Gly-Cys-...

合成工艺路线路线简述

    📜N-Dansyl-Glycine Tert-Butyl Ester置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 3.0H,以81%的收率获得丹磺酰甘氨酸
    参考文献:Rheb和k‐ras4B Gtpases的合成
    标题:Rheb和k‐ras4B Gtpases的合成
    摘要:现在可用!法尼基化和羧甲基化的rheb(见图)和k‐ras4B Gtpases通过表达的蛋白质连接和固相脂肽合成相结合,以有用的量合成.蛋白质的功能已通过生化,生物物理和基于细胞的研究证明.
    Doi:10.1002/anie.201001884

    专利信息


    专利号:US-12006540-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
    发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
    权利人:UNIV COLUMBIA
    摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

    专利号:US-5419966-A
    优先权日:1991-06-10
    标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
    发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
    权利人:MICROPROBE CORP
    摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

    专利号:US-11959137-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

    专利号:US-2024376536-A1
    优先权日:2015-09-28
    标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    专利号:US-2022411860-A1
    优先权日:2015-09-28
    标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    专利号:US-2023160000-A1
    优先权日:2015-09-28
    标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

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    主要参考文献


    1: Bertozo LC, Zeraik ML, Ximenes VF. Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase. Anal Biochem. 2017 Sep 1;532:29-37. doi: 10.1016/j.ab.2017.05.029. Epub 2017 Jun 3. 8(10):e76849. doi: 10.1371/journal.pone.0076849.
    3: Bramhall J. Use of the fluorescent weak acid dansylglycine to measure transmembrane proton concentration gradients. Biochemistry. 1986 Jul 1;25(13):3958-62. doi: 10.1021/bi00361a033. 6(2):23. doi: 10.3390/biom6020023.
    5: Muller N, Lapicque F, Drelon E, Netter P. Binding sites of fluorescent probes on human serum albumin. J Pharm Pharmacol. 1994 Apr;46(4):300-4. doi: 10.1111/j.2042-7158.1994.tb03798.x. 8(1):47-52. doi: 10.1078/0944-7113-00003. 61(13):649-53. doi: 10.1007/BF01487581. 115(12):2910-5. doi: 10.1021/jp2009463. Epub 2011 Mar 8. 18(1):9-17. doi: 10.1007/s00775-012-0944-6. Epub 2012 Oct 18.

    合成参考文献


    参考文献:10.1134/s0006297911060149
    摘要:Sviridov AV, Zelenkova NF, Vinokurova NG, Ermakova IT, Leontievsky AA. New approaches to identification and activity estimation of glyphosate degradation enzymes. Biochemistry (Mosc). 2011 Jun;76(6):720–5. doi: 10.1134/s0006297911060149.
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