CAS: 769908-13-6; (3R,5R,E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)-3,5-Dihydroxyhept-6-Enoic Acid

英文名称(3R,5R,E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)-3,5-Dihydroxyhept-6-Enoic Acid
中文名称(3R,5R,6E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-3,5-二羟基-6-庚烯酸
IUPAC名称(3R,5R,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
其它别名(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid; (3R,5R,E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)-3,5-Dihydroxyhept-6-Enoic Acid; (E,3R,5R)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-Yl]-3,5-Dihydroxyhept-6-Enoic Acid; 6-Heptenoic Acid, 7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-, (3R,5R,6E)-; (3R,5R,6E)-Pitavastatin; Monocalcium Bis[(3R,5R,E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)Quinolin-3-yl)-3,5-Dihydroxyhept-6-Enoate]; Pitavastatin (3R,5R)-Isomer; *lercanidipine Impurity 53
CAS编号769908-13-6
MFCD编号:MFCD19440904
分子式:C25H24FNO4分子量:421.47
产品CID: 1762360
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: VGYFMXBACGZSIL-FUTHQCHMSA-N
InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-1
计算化学: 氢键受体数6.0氢键供体数3.0可旋转键数8.0

MSDS等安全信息

警示词Warning
危险描述H361-
防范说明P201-P202-P280-P308+P313-P405-P501-

上下游产品

heptan-2-exo-yl (3S,5R,6E)-7--3,5-dihydroxy-6-heptenoate(4R)-4,7,7-trimethyl-3-exo-(1-naphthyl)bicyclo2.2.1heptan-2-exo-yl (3S,5R,6E)-7-2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl-3,5-dihydroxy-6-heptenoate (+/-)-E-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-6-heptenoic acid ethyl ester 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline -3,5-dihydroxy-6-heptenoic acid ,15-lactone(3S,5R,6E)-7-2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl-3,5-dihydroxy-6-heptenoic acid ,15-lactone

合成工艺路线路线简述

📜(E)-(S)-5-[2-Cyclopropyl-4-(4-Fluoro-Phenyl)-Quinolin-3-Yl]-3-Hydroxy-Pent-4-Enoic Acid Methyl Ester置于sodium Hydroxide,Tetramethylammonium Triacetoxyborohydride,Lithium Diisopropyl Amide体系中,用溶剂黄146 作为反应溶剂,化学反应生成 (3R,5R,6E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-3,5-二羟基-6-庚烯酸
参考文献:与强效合成他汀类药物nk-104相关的两对具有3,5-二羟基庚酸链对映体的系统手性合成的首次.
标题:与强效合成他汀类药物nk-104相关的两对具有3,5-二羟基庚酸链对映体的系统手性合成的首次.
摘要:报道了具有有效的合成他汀类药物nk-104的两对具有3,5-二羟基庚酸链对映体的系统手性合成.通过非对映异构拆分可有效地获得一对合成二醇异构体(nk-104及其对映异构体).一对抗二醇异构体(3-Epimer和5-Epimer)的合成通过不对称的醇醛缩醛反应有效地完成,然后进行抗立体选择性还原为关键步骤.它们的纯度测定通过手性HPLC分析进行.
DOI:10.1016/s0960-894X(99)00519-3