CAS: 7470-38-4; 4-(4-Morpholinyl)Benzoic Acid

上下游产品

CAS号110-91-8 吗啉 | CAS号451-46-7 4-氟苯甲酸乙酯 | CAS号1194-02-1 对氟苯腈 | CAS号10282-31-2 4-(4-氰苯基)吗啉 | CAS号934012-95-0 Benzonitrile, 2... | CAS号23676-05-3 4-(4-吗啉基)苯甲酸甲酯 | CAS号655-32-3 2,2,2,4'-四氟苯乙酮 | CAS号23676-05-3 4-(4-吗啉基)苯甲酸甲酯 | CAS号280556-71-0 4-吗啡啉基苄醇 | CAS号720720-60-5 4-(3-氧代吗啉)苯甲酸

2,2,2,4'-四氟苯乙酮置于sodium Hydroxide,三乙胺体系中,用 二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.5H,反应生成 4-吗啉基苯甲酸
参考文献:一种制备 4-氮取代苯甲酸的实用方法
标题:一种制备 4-氮取代苯甲酸的实用方法
摘要:描述了一种有效且实用的制备 4-氮取代苯甲酸的方法.我们的方法包括 2,2,2,4'-四氟苯乙酮与胺的芳香取代,然后是苯甲酸的卤仿反应.在该方法中,即使对于亲核性较低的 7-,8-和 9-元胺 1 当量.使用时,相应的苯甲酸以中等至极好的收率获得.由于包括纯化在内的实验步骤简单,该方法适用于大规模合成.
DOI:10.1246/cl.2006.1090

专利信息

专利号:US-6689882-B2
优先权日:2000-05-18
标 题 :Process for the synthesis of morpholinylbenzenes
发明人：TIAN WEI
权利人:ASTRAZENECA AB
摘要:A new improved process for synthesizing morpholinylbenzenes of the formula I by reacting morpholine of formula II with a substituted benzene of formula III, wherein morpholine is used as a reactant and as the only one solvent.

专利号:US-2003171581-A1
优先权日:2000-05-18
标题:Process for the synthesis of morpholinylbenzenes

专利号:US-2008045708-A1
优先权日:2000-05-18
标 题 :New Process for the Synthesis of Morpholinylbenzenes

专利号:US-10308595-B2
优先权日:2013-02-15
标 题:Albicidin derivatives, their use and synthesis
发明人：SUESSMUTH RODERICH; KRETZ JULIAN; SCHUBERT VIVIEN; PESIC ALEXANDER; HUEGELLAND MANUELA; ROYER MONIQUE; COCIANCICH STEPHANE; ROTT PHILIPPE; KERWAT DENNIS; GRAETZ STEFAN
权利人:UNIV BERLIN TECH
摘要:Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

专利号:CA-2407473-A1
优先权日:2000-05-18
标题:A new process for the synthesis of morpholinylbenzenes

专利号:US-2005010045-A1
优先权日:2000-05-18
标题:Process for the synthesis of morpholinylbenzenes