CAS: 609-08-5; Diethyl 2-Methylmalonate

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Diethylaminomethyl-Methyl-Malonic Acid Diethyl Ester置于samarium Diiodide体系中,用 四氢呋喃 作为反应溶剂,以77%的收率获得产物甲基丙二酸二乙酯
参考文献:Smi2-Mediated Carbon−carbon Bond Fragmentation In α-Aminomethyl Malonates
标题:Smi2-Mediated Carbon−carbon Bond Fragmentation In α-Aminomethyl Malonates
摘要:A New And Efficient Samarium Diiodide-Promoted Carbon-Carbon Bond Fragmentation Reaction Of Alpha-Aminomethyl Malonates,Taking Place Normally At Room Temperature And Generating The Corresponding Deaminomethylation Products In 74-94% Yields,Is Reported. The Presence Of The Amino Group Is Necessary For The Success Of The Current Transformation.
DOI:10.1021/ol901608K

专利信息

专利号:US-5840814-A
优先权日:1996-08-07
标题 :Multi-arm star polymers having a well-defined core and methods for the synthesis thereof
发明人：MAJOROS ISTVAN J; MARSALKO TIMEA M; KENNEDY JOSEPH P
权利人:UNIV AKRON
摘要:The synthesis of star polymers having well-defined arms emanating from well-defined and readily controllable calix n!arene (n=4 to 16) cores are described. The synthesis is particularly suitable for polyisobutylene and/or polysiloxane star polymers. The synthesis has been achieved using carbocationic and/or anionic ring-opening polymerization techniques to form polymer arms of desired molecular weights, then separately preparing the calixarene derivative core, and finally, linking the arms to the core by transesterification or hydrosilation.

专利号:US-7470822-B2
优先权日:2004-10-05
标题:C10 dialdehyde, synthetic method thereof, and synthetic method of beta-carotene using the same
发明人：KOO SANGHO; GUHA SAMAR KUMAR
权利人:MYONGJI UNIV IND & ACAD COOP
摘要:The novel intermediate compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the practical synthetic process for preparing β-carotene by the use of the above novel compound are disclosed. The synthesis of β-carotene is characterized by the double elimination reactions of the C 40 compound containing both the benzenesulfonyl group and the group X (either halogen or ether), which can be prepared by the coupling reaction of the novel C 10 dialdehyde with two equivalents of the C 15 allylic sulfone, followed by the functional group transformation of the resulting C 40 diol either to the corresponding halide or to the ether, to produce the fully conjugated polyene chain.

专利号:US-9428524-B2
优先权日:2010-05-25
标 题:Synthetic process for the manufacture of ecteinascidin compounds
发明人：MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN
权利人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN; PHARMA MAR SA
摘要:This invention relates to compounds of formula II: wherein R 1 , R 2 , Prot SH , and Prot NH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.

专利号:WO-9955664-A1
优先权日:1998-04-24
标 题 :Preparation of carbocyclic compounds
发明人：BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
权利人:GILEAD SCIENCES INC; BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-6518438-B2
优先权日:1996-08-23
标题:Preparation of cyclohexene carboxylate derivatives
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:EP-1105359-B1
优先权日:1998-08-21
标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
发明人：CHATURVEDI SURENDRAKUMAR
权利人:PE CORP NY
摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.