CAS: 592-82-5; Butyl Isothiocyanate

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628-03-5 4404-45-9 4426-83-9

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CAS号75-15-0 二硫化碳 | CAS号109-73-9 正丁胺 | CAS号2769-64-4 异腈基正丁烷 | CAS号400-59-9 N-Butyltrifluor... | CAS号18879-99-7 Butyldithi°Carb... | CAS号628-05-7 1-硝基戊烷 | CAS号96989-50-3 二-2-吡啶基 硫碳酸 | CAS号56134-96-4 ethyl N-butylca... | CAS号10583-85-4 1-Butyl-4-imida... | CAS号4316-42-1 N-正丁基咪唑 | CAS号1792-17-2 1,3-二丁基脲 | CAS号693-64-1 N,N-dibutylmeth... | CAS号108168-84-9 4-n-butyl-5-(n-... | CAS号108168-85-0 2,4-dibutyl-1,2... | CAS号132783-18-7 cis-4,5-Dimethy... | CAS号134110-61-5 trans-4,5-Dimet... | CAS号4253-22-9 二丁基锡硫化 | CAS号21198-52-7 1-amino-3-butyl...

N-Butyldithiocarbamate置于iron(Iii) Chloride,Sodium Acetate体系中,用 丙酮 作为反应溶剂,化学反应 2.0H,以90%的收率获得产物丁基异硫氰酸酯
参考文献:铁促进的一锅法:异硫氰酸酯的合成
标题:铁促进的一锅法:异硫氰酸酯的合成
摘要:摘要 我们已经建立了一种简便且通用的合成方法,用于在温和条件下,在环保,廉价,易得的铁催化剂存在下,由各自的胺构建异硫氰酸酯.该反应通过形成硫代氨基甲酸盐作为中间体来提供目标产物.在优化的反应条件下,芳香胺和脂肪胺均以中等至高产率提供各自的目标产物.然而,吸电子取代基在室温下难以得到目标产物,而在中等温度下它们以非常好的收率获得最终产物.此外,机理研究表明,合成路线涉及基于铁的后续加硫和脱硫反应.图形概要
DOI:10.1080/10426507.2020.1716755

专利信息

专利号:US-9458111-B2
优先权日:2010-07-29
标题:Process for the synthesis of substituted urea compounds
发明人：LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS
权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A
摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

专利号:US-2015197503-A1
优先权日:2012-07-27
标题 :Process for the synthesis of substituted urea compounds
发明人：RUSSO DOMENICO; WAHNON JORGE BRUNO REIS; MATON WILLIAM; ESZENYI TIBOR
权利人:BIAL PORTELA & Cª S A
摘要:A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

专利号:US-9751868-B2
优先权日:2012-02-28
标题 :Benzocyanine compounds
发明人：HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G; NLEND MARIE CHRISTINE
权利人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G; NLEND MARIE CHRISTINE; PIERCE BIOTECHNOLOGY INC; DYOMICS GMBH
摘要:Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

专利号:US-2017158858-A9
优先权日:2013-03-07
标 题:Cyanine compounds
发明人：HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G
权利人:HERMANSON GREG; CZERNEY PETER T; DESAI SURBHI; WENZEL MATTHIAS S; DWORECKI BOGUSLAWA R; LEHMANN FRANK G
摘要:Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

专利号:US-2013123493-A1
优先权日:2010-07-29
标题 :Process for the synthesis of substituted urea compounds

专利号:EP-2595953-A1
优先权日:2010-07-23
标题 :Process for the synthesis of isothiocyanates and derivatives thereof and uses of same