专利号:US-6281331-B1 优先权日:1998-03-23 标 题 :Methods and compositions for peptide synthesis 发明人:KANG MYUNG-CHOL; BRAY BRIAN; LICHTY MAYNARD; MADER CATHERINE 权利人:TRIMERIS INC 摘要:The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.
专利号:US-5962294-A 优先权日:1992-03-09 标题 :Compositions and methods for the identification and synthesis of sialyltransferases 发明人:PAULSON JAMES C; WEN XIAOHONG; LIVINGSTON BRIAN; GILLESPIE WILLIAM; KELM SORGE; BURLINGAME ALMA L; MEDZIHRADSZKY KATALIN 权利人:UNIV CALIFORNIA; CYTEL CORP 摘要:DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.
专利号:US-5401844-A 优先权日:1983-04-11 标 题 :Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines 发明人:AYLING JUNE E; BAILEY STEVEN W 权利人:UNIV SOUTH ALABAMA 摘要:6-[2'-Amino-2',2'-disubstituted-ethylamino]-pyrimidines of the structure: ##STR1## in which X=H, NH 2 or NO 2 , which are novel intermediates in the synthesis of quinoid 6,6-disubstituted-dihydro- and 6,6-disubstituted-tetrahydro-pteridines, are claimed.
专利号:SK-635190-A3 优先权日:1989-12-20 标题:Bcrf1 protein of epstein-barr virus being capable of inhibiting synthesis of gamma-interferon, expression vector for synthesis thereof, and pharmaceutical composition containing thereof
专利号:US-2017349628-A1 优先权日:2014-10-02 标 题:Synthesis of Cell Penetrating Peptides for Drug Delivery and Stem Cell Applications
专利号:WO-2024233408-A1 优先权日:2023-05-05 标 题 :Compositions comprising kombucha and their uses 发明人:DOUCET OLIVIER; PUJOS MURIEL; CHAMAYOU-ROBERT CECILE 权利人:COTY INC; JOYAL DAVID; DOUCET OLIVIER; PUJOS MURIEL; CHAMAYOU ROBERT CECILE 摘要:The invention is generally directed to identification and use of a kombucha extract, alpha-glucan oligosaccharide, or a mixture thereof that is capable of increasing skin barrier protection as assessed by ability to increase cell differentiation certain biomarkers of as measured by expression of filaggrin and involucrin in particular. A composition may be used in a method of improving an aesthetic appearance of skin of a human affected by weakened skin barrier comprising topically applying thereto a therapeutically effective amount of an active agent, wherein the active agent increases synthesis of involucrin and/or filaggrin by greater than 40% when applied ex vivo to human skin keratinocytes at a concentration of at least 0.45% w/w in a cosmetically acceptable vehicle.
参考文献:10.1021/jm0511029 摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029.