CAS: 56844-38-3; 2,4-Dichloro-5-Methylthieno[2,3-D]Pyrimidine
该化合物是一种杂交循环化合物,其特点是其独特的结构,其中包括一种硫氨基框架,该化合物有两种氯原子和附于环的甲基组,有助于其化学反应和潜在的生物活动;该化合物在室内温度下一般是固体,在有机溶剂中可能表现出中等溶解性;氯分成分的存在往往会增强化合物的亲眼性,从而影响其与生物系统的互动. 2,4-二氯-5-甲基硫代氨基[2,3-d] 基胺可能因其在药物中的潜在用途,特别是作为开发新治疗剂的垫子,对药用化学感兴趣,因此可能对药用化学感兴趣.其合成和特征涉及标准的有机化学技术,并可能研究其对各种生物目标的影响.与许多化学物质一样,在处理该化合物时,应注意安全防范措施,因为其可能对健康造成风险,取决于接触程度.
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43088-67-1 18740-39-1 76872-23-6物理性质
MSDS等安全信息
上下游产品
CAS号4623-55-6 2-氨基-4-甲基噻吩-3-甲腈 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号75860-79-6 5-甲基-噻吩并[2,3-d]... | CAS号83259-31-8 2-氯-5-甲基噻吩并[2,3-d]嘧啶 | CAS号56844-37-2 2-chloro-5-meth...合成工艺路线路线简述
📜5-甲基-噻吩并[2,3-D]嘧啶-2,4(1H,3H)-二酮置于n,N-二甲基苯胺,三氯氧磷体系中,化学反应 16.0H,以31%的收率获得产物2,4-二氯-5-甲基噻吩并[2,3-D]嘧啶
参考文献:The Highly Potent And Selective Dipeptidyl Peptidase Iv Inhibitors Bearing A Thienopyrimidine Scaffold Effectively Treat Type 2 Diabetes
标题:The Highly Potent And Selective Dipeptidyl Peptidase Iv Inhibitors Bearing A Thienopyrimidine Scaffold Effectively Treat Type 2 Diabetes
摘要:New Dipeptidyl Peptidase Iv Inhibitors Were Designed Based On Alogliptin Using A Scaffold-Hopping Strategy. All Of The Compounds Constructed On A Thienopyrimidine Scaffold Demonstrated Good Inhibition And Selectivity For Dpp-Iv. Compound 10D Exhibited Subnanomolar (Ic50 = 0.33 Nm) Dpp-Iv Inhibitory Activity,Good In Vivo Efficacy And An Acceptable Pharmacokinetic Profile. A Pharmacokinetic-Driven Optimization Of 10D May Lead To A New Class Of Clinical Candidate Dpp-Iv Inhibitors. (C) 2010 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2010.10.016
专利信息
专利号:RU-2197492-C2
优先权日:1996-10-24
标题:Thienopyrimidines with inhibitory effect with respect to phosphodiesterase v (pde v), method of their synthesis and pharmaceutical composition
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考DOI号:10.1016/j.bmcl.2014.03.052
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