CAS: 5579-84-0; N-Methyl-2-(Pyridin-2-yl)Ethanamine Dihydrochloride

相似化合物

3343-39-3 2706-56-1 244094-70-0

上下游产品

betahistine α-picoline 2-(2-Hydroxyethyl)pyridine

专利信息

专利号:US-10920229-B2
优先权日:2014-07-16
标 题:Method for improving heterologous synthesis of Escherichia coli into polyketides and use of same
发明人：WANG YONG; XIONG ZHIQIANG; SONG SHUJIE; LIU QIAOXIA; WANG JIANFENG
权利人:SHANGHAI INST BIOLOGICAL SCIENCES CAS; CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES
摘要:The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.

专利号:US-7906460-B2
优先权日:2000-12-13
标 题:Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnaturalâ€? UDP- and TDP-nucleotide sugars
发明人：THORSON JON; NIKILOV DIMITAR B
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified E p or other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

专利号:US-7083952-B2
优先权日:2000-03-01
标题 :Nucleotide sequences coding for proteins involved in the biosynthesis of L-serine, an improved method for the microbial production of L-serine and a genetically modified microorganism suitable therefor
发明人：ZIEGLER PETRA; EGGELING LOTHAR; SAHM HERMANN; PETERS-WENDISCH PETRA
权利人:FORSCHUNGSZENTRUM JUELICH GMBH
摘要:The present invention relates to nucleotide sequences of coryneform bacteria, coding for proteins involved in the bio-synthesis of L-serine and to methods for the isolation thereof. The invention further relates to an improved method for the production of L-serine. In addition, the present invention relates to the use of L-serine in the food, animal feed and/or pharmaceutical industries or in human medicine.

专利号:US-6455688-B1
优先权日:1994-04-21
标 题 :Plant gene specifying acetyl coenzyme A carboxylase and transformed plants containing same
发明人：SLABAS ANTONI RYZSARD; ELBOROUGH KIERAN MICHAEL; BRIGHT SIMON WILLIAM JONATHAN; FENTEM PHILLIP ANTHONY
权利人:ZENECA LTD
摘要:DNA sequence of an acetyl Coenzyme A carboxylase from plants are inserted into the genome of plants in sense or antisense orientation in order to inhibit expression of the gene product of the endogenous ACCase gene, resulting in reduced conversion of the enzyme's substrate, acetyl Coenzyme A, to fatty acid synthesis, leaving the substrate available for diversion into other biosynthesis pathways. One such diversion may be accomplished by providing the plant genome with genes specifying the synthesis of polyhydroxyalkanoate polymers.

专利号:US-7160711-B2
优先权日:2001-08-06
标题:Coryneform bacteria which produce chemical compounds I
发明人：BATHE BRIGITTE; KREUTZER CAROLINE; MOCKEL BETTINA; THIERBACH GEORG
权利人:DEGUSSA
摘要:The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

专利号:US-2005287169-A1
优先权日:2003-06-17
标 题 :Methods of use of genes of pyridoxal 5'-phosphate biosynthesis in Bacillus subtilis: avirulent strains for vaccines, and methods for identification of antibacterial agents
发明人：BELITSKY BORIS R
权利人:BELITSKY BORIS R
摘要:Methods and compositions comprising a pathogenic bacterial strain having a non-reverting mutation in a pdx gene encoding an enzyme involved in pyridoxal-5′-phosphate synthesis are provided, for use in vaccines, and methods for identification of inhibitors of the enzyme for use as an antibacterial agent are provided.