CAS: 52218-37-8; 5-Acetamidonaphthalene-1-Sulfonyl Chloride

相似化合物

886496-53-3 160206-27-9 5690-20-0

上下游产品

5-acetamidonaphthalene-1-sulfonic acid sodium 5-acetamido-1-naphthalenesulfonate 1-aminonaphthalene-5-sulfonic acid acetic anhydride N-(5-p-tolylsulfamoyl-naphthalen-1-yl)-acetamideN-(5-p-tolylsulfamoyl-naphthalen-1-yl)-acetamide N-[5-(4-chloro-phenylsulfamoyl)-naphthalen-1-yl]-acetamideN-[5-(4-chloro-phenylsulfamoyl)-naphthalen-1-yl]-acetamide N-[5-[[(2-phenylethyl)amino)sulfonyl]-1-naphthalenyl]acetamide N-[5-[(phenylamino)sulfonyl]-1-naphthalenyl]acetamide

📜Sodium 5-Aminonaphthalene-1-Sulfonate置于氯磺酸体系中,化学反应生成 5-乙酰氨基萘-1-磺酰氯
参考文献:Caffeoyl Naphthalenesulfonamide Derivatives As Hiv Integrase Inhibitors
标题:Caffeoyl Naphthalenesulfonamide Derivatives As Hiv Integrase Inhibitors
摘要:Hiv-1 Integrase (In) Is An Essential Enzyme For Retroviral Replication And A Rational Target For The Design Of Anti-Aids Drugs. In The Present Study,We Have Designed,Synthesized And Tested A Series Of Caffeoyl Naphthalenesulfonamide Derivatives As Hiv Integrase Inhibitors. Among These Compounds,We Found That Hiv Integrase Inhibitory Activities Of Compounds Iii-3 And Iii-4 Were More Potent Than L-Chicoric Acid (Ic50 = 11.8 Mug/ml) And Others Were Comparable To L-Chicoric Acid. Furthermore,The Structure-Activity Relationships Of These Compounds Were Studied. The Information Gathered From This Paper Will Be Useful In The Development And Design Of Hiv-1 Integrase Inhibitors In The Future. (C) 2003 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/s0968-0896(03)00372-9