CAS: 521-31-3; 5-Amino-2,3-Dihydro-1,4-Phthalazinedione

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5-Amino-2,3-Dihydro-1,4-Phthalazinedione Sodium Salt置于sodium Hydroxide体系中,化学反应生成 鲁米诺
参考文献:鲁米诺异构体在水溶液中的物理化学性质
标题:鲁米诺异构体在水溶液中的物理化学性质
摘要:摘要 获得并描述了两种鲁米诺异构体,2,4-二氨基异吲哚啉-1,3-二酮和8-氨基-4-羟基酞嗪-1(2H)-One,并研究了它们的理化性质.紫外光谱和荧光数据表明,在水溶液中,2,4-Diaminoisoindoline-1,3-Dione 异构化为 8-Amino-4-Hydroxyphthalazin-1(2H)-One,速度为转变取决于 Ph 值.已确定 2,4-Diaminoisoindoline-1,3-Dione 和 8-Amino-4-Hydroxyphthalazin-1(2H)-One Luminol 异构体的热力学解离常数.
DOI:10.1016/j.Molstruc.2017.10.004

专利信息

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:US-9929363-B2
优先权日:2013-08-05
标题:Composition and synthesis of aggregation-induced emission materials
发明人：TANG BENZHONG; Xie ni; LAM WING YIP
权利人:UNIV HONG KONG SCI & TECH
摘要:The present subject matter relates to compositions containing and synthesis of fluorescent materials e made from tetraphenylethylene (TPE) derivative compounds exhibiting aggregation induced emission (AIE) properties. Further contemplated herein are applications for TPE derivative compounds such as electroluminescent devices since they have a high efficiency, low turn on voltage, and excellent brightness. Additionally, application of TPE derivatives exhibiting AIE properties in various fields such as OLEDs, fingerprinting and forensic technology, and various other biological and industrial sectors are discussed.

专利号:WO-2004113530-A1
优先权日:2003-06-18
标题:Polynucleotide for synthesis of labeled protein
发明人：NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
权利人:MITSUBISHI CHEM CORP; NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
摘要:A process for producing a labeled protein, comprising translating a gene template in the presence of a labeled compound having a label portion consisting of a labeled substance and an acceptor portion consisting of a compound capable of binding to the C-terminus of protein synthesized by a translation system. In particular, there are provided a polynucleotide for use in synthesis of labeled protein characterized by having the capability of enhancing labeling efficiency through addition to the 3’ end of a base sequence coding for target protein within the gene template and provided a process for producing a labeled protein that is carried out with the use of the polynucleotide.

专利号:US-5679773-A
优先权日:1995-01-17
标题 :Reagants and methods for immobilized polymer synthesis and display
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.

专利号:US-2014350235-A1
优先权日:2013-05-23
标题:In situ oligonucleotide synthesis on a paramagnetic support
发明人：AKHRAS MICHAEL S; JENSEN MICHAEL A
权利人:AKHRAS MICHAEL S; JENSEN MICHAEL A; UNIV LELAND STANFORD JUNIOR
摘要:A novel method for attaching oligonucleotides to a paramagnetic solid support is disclosed. Conventional methods of attachment require that oligonucleotides be pre-synthesized with specific end modifications, which is laborious and expensive. Instead, we attached oligonucleotides to paramagnetic beads by direct synthesis of the oligonucleotides on the surface of the beads. An external magnet was used to hold the paramagnetic beads in place during solid-phase synthesis. A magnetic force was applied directly to the beads to prevent their loss, in particular, during reagent purge-to-waste steps that involved high-pressure drain or vacuum. This method can be adapted for use in any laboratory working with conventional synthesis automation, and can be employed, for example, with single columns and multi-well titer plates.

专利号:US-2022280429-A1
优先权日:2021-03-03
标 题:Tunable leukocyte-based biomimetic nanoparticles and methods of use
发明人：ZINGER ASSAF YOSEF; TARABALLI FRANCESCA
权利人:METHODIST HOSPITAL
摘要:Disclosed are liposomal formulations and biomimetic proteolipid nanoparticles that possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types. Leukocyte-based biomimetic nanoparticles are disclosed that incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the in vivo behavior of these nanoparticles and alter their efficacy. Here it is shown that, while increasing the protein:lipid ratio to a maximum of 1:20 (wt./wt.) maintained the nanoparticle's structural properties, increasing protein content resulted in improved targeting of inflamed endothelium in two different animal models. The combined use of a microfluidic, bottom-up approach, and the tuning of key synthesis parameters enabled the synthesis of reproducible, biomimetic nanoparticles for the improved targeted nanodelivery of a variety of inflammatory-based conditions, including particular cancers such as human breast cancer, and TNBC, in particular.