CAS: 504-73-4; 4,5-Dihydro-Isoxazole

专利信息

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

专利号:US-2023339844-A1
优先权日:2020-09-17
标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-4269772-A
优先权日:1980-01-14
标 题 :Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
发明人：MELILLO DAVID G; RYAN KENNETH M
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R5 and R6 are removable protecting groups.