Sphaerophorolcarboxylic Acid 反应生成 5-庚基苯-1,3-二醇 参考文献:Synthesis Of 3,5,7-Triketo Acids And Esters And Their Cyclizations To Resorcinol And Phloroglucinol Derivatives. Models Of Biosynthesis Of Phenolic Compounds 标题:Synthesis Of 3,5,7-Triketo Acids And Esters And Their Cyclizations To Resorcinol And Phloroglucinol Derivatives. Models Of Biosynthesis Of Phenolic Compounds 摘要: DOI:10.1021/ja01001A060
专利号:US-10981850-B2 优先权日:2019-04-15 标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives 发明人:PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V 权利人:UNIV BOSTON 摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
专利号:US-5386019-A 优先权日:1992-01-15 标 题 :Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers 发明人:DANISHEFSKY SAMUEL J; DUSHIN Russell; HAIT WILLIAM N 权利人:UNIV YALE 摘要:The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.
专利号:US-3940421-A 优先权日:1971-12-20 标题 :Intermediates for the preparation of thienobenzopyrans and thiopyranobenzopyrans 发明人:RAZDAN RAJ K; PARS HARRY G 权利人:LITTLE INC A 摘要:Novel thienobenzopyrans and thiopyranobenzopyrans represented by the formula ##SPC1## n Wherein m and n are each 0, 1, 2 or 3 and m + n is 2 or 3; R 1 is loweralkyl; R 2 is alkyl or cycloalkylloweralkyl and R 3 is hydrogen, loweralkyl, loweralkanoyl, carbamyl, N-loweralkylcarbamyl, N,N-diloweralkylcarbamyl, phosphonyl, hemisuccinate or an ester of another such acid, phosphate, dialkylaminoalkyl of the structure ##EQU1## or acid addition salt thereof, or dialkylaminoalkylanoyl of the structure ##EQU2## or acid addition salt thereof, wherein x is 1 through 6 and R 4 and R 5 are loweralkyl; the loweralkyl groups containing from 1 through 6 carbon atoms, the alkyl groups containing from 1 through 20 carbon atoms and the cycloalkyl groups containing from 3 through 8 ring carbon atoms. Novel intermediates for the synthesis of these compounds are also disclosed as well as methods for making the compounds.
专利号:US-2022127649-A1 优先权日:2019-01-30 标题:Engineered cells for improved production of cannabinoids 发明人:NOBLE MICHAEL A; MOORE JONATHAN; LI JINGYI; LECHNER ANNA 权利人:GENOMATICA INC 摘要:The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing synthesis of olivetolic acid, olivetolic acid derivatives and/or cannabinoids.
专利号:WO-2020214574-A1 优先权日:2019-04-15 标 题 :One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives
专利号:WO-9314099-A1 优先权日:1992-01-15 标题 :Synthesis of inhibitors of calmodulin-mediated enzymes
参考文献:10.1007/978-981-99-2302-1_12 摘要:Singh IP, Gore DD, Karkhele S, Vairappan CS. The Chemistry and Pharmacology of Mandarin Orange (Citrus reticulata). 2023. In: Recent Advances in Pharmaceutical Innovation and Research. 参考文献:10.1007/s10886-005-1349-6 摘要:JONES TH, BRUNNER SR, EDWARDS AA, DAVIDSON DW, SNELLING RR. 6-Alkylsalicylic Acids and 6-Alkylresorcylic Acids from Ants in the Genus Crematogaster from Brunei. Journal of Chemical Ecology. 2005 Feb;31(2):407–17. doi: 10.1007/s10886-005-1349-6. 参考文献:10.1038/s42003-020-01530-y 摘要:Blaskovich MAT, Kavanagh AM, Elliott AG, Zhang B, Ramu S, Amado M, Lowe GJ, Hinton AO, Pham DMT, Zuegg J, Beare N, Quach D, Sharp MD, Pogliano J, Rogers AP, Lyras D, Tan L, West NP, Crawford DW, Peterson ML, Callahan M, Thurn M. The antimicrobial potential of cannabidiol. Communications Biology. 2021 Jan 19;4(1):7. doi: 10.1038/s42003-020-01530-y.