CAS: 487-90-1; Porphobilinogen

上下游产品

2-Cyano-3-(1-Methoxycarbonylmethyl)-4-(2-Methoxycarbonylethyl)Pyrrole 91567-90-7
Porphobilinogen Lactam 3468-98-2
Porphobilinogen Lactam Methyl Ester 32682-61-4
3-(5-Oxo-4,5,6,7-Tetrahydro-1H-Pyrrolo[2,3-C]Pyridin-3-yl)-Propionic Acid Ethyl Ester 24331-86-0
2-Cyano-3-<2-(Tetrahydro-2H-Pyran-2-yl)Oxy> Ethyl-4-(2-Methoxycarbonylethyl)Pyrrole 172667-51-5

📜5-氨基乙酰丙酸盐酸盐置于porphobilinogen Synthase Potassium Phosphate,2-巯基乙醇体系中,用56%的收率获得产物5-9氨基甲基)-4-(羧甲基)-1H-吡咯-3-丙酸
参考文献:Jones,Christopher; Jordan,Peter M.; Akhtar,Muhammad,Journal Of The Chemical Society. Perkin Transactions I,1984,# 11,P. 2625-2633
标题:Jones,Christopher; Jordan,Peter M.; Akhtar,Muhammad,Journal Of The Chemical Society. Perkin Transactions I,1984,# 11,P. 2625-2633

专利信息

专利号:WO-2022173135-A1
优先权日:2021-02-10
标题:Recombinant microorganism with improved production capacity of heme, coproporphyrin â…², uroporphyrin â…², zinc-coproporphyrin â…², zinc-uroporphyrin â…², and biliverdin, and method for production of heme, coproporphyrin â…², uroporphyrin â…², zinc-coproporphyrin â…², zinc-uroporphyrin â…², and biliverdin by using same
发明人：HAN SUNG OK; KO YOUNG JIN
权利人:UNIV KOREA RES & BUS FOUND
摘要:The present invention relates to a recombinant microorganism with improved production capability of heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢ (Zn-coproporphyrin â…¢), zinc-uroporphyrin â…¢ (Zn-uroporphyrin â…¢), and biliverdin, a preparation method therefor, and a method for production of heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢, zinc-uroporphyrin â…¢, and biliverdin by using same. In the present invention, a synergistic effect of the introduction of genes related to the C4 and C5 pathways for synthesis of 5-aminolevulinic acid (ALA), genes related to the coproporphyrin â…¢-dependent pathway, and transcriptional regulatory factors was first evidenced through the improved porphyrin productivity effect of the recombinant microorganism. In addition, in contrast to the conventional recombinant microorganisms which are induced for extracellular production by introducing an extracellular secretion protein thereinto, the present invention first identified that the extracellular secretion of heme can be remarkably increased through the strategy of modifying microorganism cell walls. The recombinant microorganism according to the present invention is provided with enhanced production capability of porphyrin-based materials through the aforementioned metabolism engineering strategy and exhibits high productivity therefor. Thus, heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢, zinc-uroporphyrin â…¢, and biliverdin, which are all high value-added materials, can be economically and efficiently produced by using the recombinant microorganism of the present invention.

专利号:US-5211938-B1
优先权日:1989-07-28
标题:Method of detection of malignant and nonmalignant lesions by photochemotherapy of photoporphyrin ix precursors
发明人：KENNEDY JAMES C; POTTIER ROY H; REID ROBERT L
权利人:UNIV KINGSTON
摘要:A method of detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin, conjunctives, respiratory, digestive and vaginal mucosa; endometrium and urothelium in which 5-aminolevulinic acid is administered to the patient in an amount sufficient to induce synthesis of protoporphyrin IX in the leisons, followed by exposure of the treated lesion to a photoactivating light in the range 350-640 nm.

专利号:WO-9724621-A3
优先权日:1995-12-29
标 题:Reagents for measuring lead levels via the quantification of porphobilinogen
发明人：ADAMCZYK MACIEJ; FISHPAUGH JEFFREY R; HEUSER KEVIN; RAMP JOHN M; WONG MARTIN
权利人:ABBOTT LAB
摘要:Immunoassay methods and reagents for measuring the levels of lead in a test sample via the quantification of porphobilinogen use antibodies prepared with compounds of Formulas (II) and (III), wherein X and Y are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to an immunogenic carrier material P wherein P is preferably bovine serum albumin. Also described are the synthesis of fluorescein tracers of the structure of Formulas (V) and (VII), wherein A and C are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to a detectable moiety Q, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.

专利号:US-8524892-B2
优先权日:2005-07-29
标题:Methods and intermediates for the synthesis of porphyrins
发明人：LINDSEY JONATHAN S; TANIGUCHI MASAHIKO; FAN DAZHONG
权利人:LINDSEY JONATHAN S; TANIGUCHI MASAHIKO; FAN DAZHONG; UNIV NORTH CAROLINA STATE
摘要:A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: n nwith (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.

专利号:US-11920171-B1
优先权日:2016-05-06
标题:Synthesis and oxidation of methane
发明人：MANSOORABADI STEVEN
权利人:UNIV AUBURN
摘要:The present disclosure describes genes and proteins of the coenzyme F430 synthetic pathway. The genes and proteins in the pathway find uses as isolated nucleic acids, transformation vectors, a transformation media, genetically modified cells, methods of modulating methanogenesis, methods of modulating methane oxidation, methods of making a tetrapyrrole compound, methods of oxidizing methane, methods of biogenic methane synthesis is provided, methods of assaying an organism for potential methanogenic or methanotrophic activity, and isolated proteins.

专利号:EP-3698780-A1
优先权日:2004-08-09
标 题 :Glycine as a diet supplement for use in the prevention and/or treatment of an infectious disease caused by a virus in a human in the need of promoting the synthesis of collagen