CAS: 4593-38-8; 5-Methyl-1-Indanone

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CAS号201230-82-2 carbon monoxide | CAS号40230-90-8 3-甲基苯基(三甲基硅)乙炔 | CAS号3751-48-2 3-(3-甲基苯基)丙酸 | CAS号620-23-5 间甲基苯甲醛 | CAS号22422-21-5 3-氯-4’-甲基苯丙酮 | CAS号313058-61-6 2-(3-methylphen... | CAS号33333-00-5 5,5-ethylenedit... | CAS号6432-79-7 [(3-methylpheny... | CAS号20232-11-5 6-甲基-1H-茚 | CAS号528-44-9 1,2,4-苯三甲酸 | CAS号33781-37-2 5-甲基-2,3-二氢-1H-茚-1-醇 | CAS号124688-08-0 2,3-DIHYDRO-2,2... | CAS号66773-15-7 5-methyl-6-nitr... | CAS号879-33-4 5-methyl-1-prop... | CAS号919077-99-9 6-amino-5-methy... | CAS号919078-00-5 6-氯-5-甲基-2,3-二氢...

📜3-甲基苄溴置于氢氧化钾,三氯化铝,草酰氯,硫酸,Sodium Hydride,N,N-二甲基甲酰胺体系中,用 乙二醇二甲醚,二氯甲烷 作为反应溶剂,化学反应 64.0H,反应生成 5-甲基-1-茚酮
参考文献:茚满亚胺.1.设计和合成(e)-2-(4,6-二氟-1-茚二亚基)乙酰胺,这是一种具有消炎和镇痛作用的强效中枢肌肉松弛剂.
标题:茚满亚胺.1.设计和合成(e)-2-(4,6-二氟-1-茚二亚基)乙酰胺,这是一种具有消炎和镇痛作用的强效中枢肌肉松弛剂.
摘要:衍生自肉桂酰胺1,(e)-N-环丙基-3-(3-氟苯基)丙-2-烯酰胺和β-甲基肉桂酰胺2,(e)-N-环丙基-3-(3)的刚性环状类似物的设计-氟苯基)丁-2-烯酰胺已导致发现有效的中枢性肌肉松弛剂(e)-2-(4,6-二氟-1-茚二亚基)乙酰胺17.化合物17还具有有效的抗炎和抗炎作用.镇痛作用.本文描述了17和67类似物的合成及其肌肉松弛,抗炎和止痛结构-活性的关系.化合物17已进入i期临床试验.
DOI:10.1021/jm020067S

专利信息

专利号:US-2007293706-A1
优先权日:2004-11-01
标 题:Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones
发明人：WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
权利人:WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
摘要:1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction.

专利号:US-2008171873-A1
优先权日:2007-01-12
标题:Synthesis of selected stereoisomers of certain substituted alcohols
发明人：HARMS ARTHUR E
权利人:HARMS ARTHUR E
摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric amine with a halogen-substituted heterocyclic compound, or a stereoisomeric ketone or aldehyde with an amino-substituted heterocyclic compound. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.

专利号:US-2011137038-A1
优先权日:2006-11-09
标题 :Synthesis of selected stereoisomers of certain substituted alcohols
发明人：HARMS ARTHUR E
权利人:HARMS ARTHUR E
摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric epoxide with an amine, a carboxylic acid, an amide, a sulfonyl, or a cyanide. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.

专利号:US-2008114172-A1
优先权日:2006-11-09
标 题 :Synthesis of Selected Stereoisomers of Certain Substituted Alcohols

专利号:US-6316437-B1
优先权日:1999-09-30
标题:Spirohydantoin compounds and uses thereof
发明人：HOFFMAN JACOB M
权利人:MERCK & CO INC
摘要:Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are typically selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-2023002426-A1
优先权日:2019-11-15
标题 :Chiral synthesis of a tertiary alcohol