CAS: 37793-53-6; 4-(N-((2-Amino-4-Oxo-3,4-Dihydropteridin-6-yl)Methyl)-2,2,2-Trifluoroacetamido)Benzoic Acid

相似化合物

119-24-4 65165-91-5 119-24-4

上下游产品

Pteroyl Azide 197151-79-4
蝶酸 Pteroic Acid 119-24-4
Folate 59-30-3

📜Pteroyl Azide置于盐酸,1,1,2,3-四甲基胍体系中,用 四氢呋喃,二甲基亚砜 作为反应溶剂,化学反应 22.5H,反应生成 N10-三氟乙酰基蝶酸
参考文献:Efficient Syntheses Of Pyrofolic Acid And Pteroyl Azide,Reagents For The Production Of Carboxyl-Differentiated Derivatives Of Folic Acid
标题:Efficient Syntheses Of Pyrofolic Acid And Pteroyl Azide,Reagents For The Production Of Carboxyl-Differentiated Derivatives Of Folic Acid
摘要:Reaction Of Folic Acid (1) With Excess Trifluoroacetic Anhydride Provides Access To Both The Previously Unknown N-10-(Trifluoroacetyl)Pyrofolic Acid (8) And Pyrofolic Acid (9). Reaction Of Either Of These Materials With Hydrazine Selectively Affords Pteroyl Hydrazide (13),Which May Be Oxidized To Pteroyl Azide (27) On A Large Scale (62% Overall From 1 Without The Need For Chromatography). Treatment Of 27 With Differentially Protected Glutamates Provides A Convenient And High-Yielding Synthesis Of Differentially Protected,Optically Pure Folates.
DOI:10.1021/ja971568J

专利信息

专利号:US-2009318627-A1
优先权日:2006-02-07
标题:Solid phase synthesis of acridinium derivatives
发明人：NATRAJAN ANAND; SHARPE DAVID; COSTELLO JIM; JIANG QINGPING
权利人:SIEMENS HEALTHCARE DIAGNOSTICS
摘要:Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium-functionalized solid-phase supports comprise a solid phase support linked to a chemiluminescent substituted acridinium compound through a linker group covalently attached to the nitrogen atom of the acridinium nucleus and the solid phase support as exemplified in FIG. 1.

专利号:US-6528631-B1
优先权日:1993-09-03
标题 :Oligonucleotide-folate conjugates
发明人：COOK PHILLIP DAN; MANOHARAN MUTHIAH; BHAT BALKRISHEN
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the α- or γ-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.

专利号:US-2014275533-A1
优先权日:2013-03-15
标题:Methods of Manufacture and Synthesis of Amino Acid Linking Groups Conjugated To Compounds Used For Targeted Imaging of Tumors

专利号:US-8044200-B2
优先权日:2005-03-16
标题 :Synthesis and purification of pteroic acid and conjugates thereof
发明人：XU LE-CUN; VLAHOV IONTCHO RADOSLAVOV; LEAMON CHRISTOPHER PAUL; SANTHAPURAM HARI KRISHNA; LI CHUNHONG
权利人:ENDOCYTE INC
摘要:Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described.

专利号:AU-2013383386-A1
优先权日:2013-03-15
标题:Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors

专利号:EP-2968614-A1
优先权日:2013-03-15
标 题:Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors