CAS: 28643-80-3; Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-Hydroxy-6-(Hydroxymethyl)-3,5-Dimethyltetrahydro-2H-Pyran-2-yl)-2,3'-Dimethyloctahydro-[2,2'-Bifuran]-5-yl)-9-Methoxy-2,4,10-Trimethyl-1,6-Dioxaspiro[4.5]Decan-7-

📜在 Sodium体系中,获得 Nigericin Sodium Salt
参考文献:Pointud,Yvon; Juillard,Jean; Jeminet,Georges,Journal De Chimie Physique Et De Physico-Chimie Biologique,1982,Vol. 79,# 1,P. 67-72
标题:Pointud,Yvon; Juillard,Jean; Jeminet,Georges,Journal De Chimie Physique Et De Physico-Chimie Biologique,1982,Vol. 79,# 1,P. 67-72

专利信息

专利号:US-5905091-A
优先权日:1996-07-03
标 题 :Enhancement of skin pigmentation by prostaglandins
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

专利号:US-12018305-B2
优先权日:2018-12-10
标题:Process for production of nigericin from Streptomyces sp. MCC-0151
发明人：SYED GULAM DASTAGER; SAHU AMIT KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:A fermentation process is provided for the synthesis of Nigericin from Streptomyces sp. having accession number MCC 0151 and its isolation with high yield. A microbial inoculant composition is provided, comprising a biologically pure culture of Streptomyces sp. MCC 0151 for the exclusive production of Nigericin with high yield.

专利号:US-9989489-B2
优先权日:2006-12-14
标 题 :Methods for calibrating an array of chemically-sensitive sensors
发明人：ROTHBERG JONATHAN; HINZ WOLFGANG; JOHNSON Kim; BUSTILLO JAMES
权利人:LIFE TECHNOLOGIES CORP; LIFE TECHNNOLOGIES CORP
摘要:Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

专利号:US-2011104052-A1
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres
发明人：BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
权利人:UNIV JOHNS HOPKINS
摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

专利号:US-10287298-B2
优先权日:2014-09-12
标题 :Nitrogen-containing analogs of salinomycin, synthesis and use against cancer stem cells and malaria
发明人：MEHRPOUR MARYAM; RODRIGUEZ RAPHAEL; HIENZSCH ANTJE; TRANG MAI; HAMAI AHMED
权利人:CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; UNIV PARIS DESCARTES; UNIVERSTIE PARIS SUD
摘要:The present invention concerns compounds of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diasteroisomers thereof formula (I): wherein at least one of W, X and Y is selected from the group consisting of —NR 1 R 2 ; —NR 3 —(CH 2 ) n —NR 4 R 5 ; —O—(CH 2 ) n —NR 4 R 5 ; —NR 3 —(CH 2 ) n —N′R 6 R 7 R 8 ; and —O—(CH 2 ) n —N′R 6 R 7 R 8 and Z is a functional group capable of chelating iron salts. The present invention also concerns the compounds of formula (I) for use as a drug, in particular, in the treatment of cancer and malaria.

专利号:US-9290529-B2
优先权日:2011-10-24
标题:Carbonic anhydrase inhibitors and method of their production
发明人：BRYNDA JIRI; CIGLER PETR; GRUNER BOHUMIR; MALOY REZACOVA PAVLINA; MADER PAVEL; SICHA VACLAV; BAKARDJIEV MARIO; HOLUB JOSEF; DZUBAK PETR; HAJDUCH MARIAN
权利人:USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY V V I; USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY V V I; USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY V V I; UNIV PALACKEHO
摘要:Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.