CAS: 2797-51-5; Quinoclamine

该化合物是属于quinline衍生物类别的化学化合物,其特点是其异环结构,包括一个quinoline环系统.Quinoclamine主要因其药理特性而得到承认,特别是用作抗疟剂.该化合物展示了一系列生物活动,包括潜在的抗微生物和抗炎效应.其行动机制被认为涉及干扰病原体的核酸合成.基诺clami通常以晶体固态的形式出现,在有机溶剂中溶解,尽管其在水中的溶解性有限.安全数据表明,与许多化学物质一样,它应该谨慎处理,因为如果摄入或吸入,它可能会对健康造成危害.

结构式图片

欧盟法规

统一分类与标签"欧盟管控危险化学品"ECHA物质欧盟农药活性物质ECHA物质OtherC&L通报化妆品禁用物质清单工作场所安全标识要求食品接触材料-禁用CMR物质REACH预注册废弃物危险特性清单

上下游产品

2-叠氮基-3-氯萘-1,4-二酮 2-Azido-3-Chlor-1,4-Naphthochinon 15707-35-4
2-氨基-1,4-萘醌 2-Amino-1,4-Naphthoquinone 2348-81-4
2,3-二氯-1,4-萘醌 2,3-Dichloro-1,4-Naphthoquinone 117-80-6
3-Chloro-2-(Piperazin-1-yl)-1,4-Naphthoquinone 104309-89-9

合成工艺路线路线简述

  • 合成目标产物 2-Amino-3-Chloro-1,4-Naphthoquinone 主要起始原料 2,3-Dichloro-1,4-Naphthoquinone
  • (文献来源)合成步骤主要原料 2,3-Dichloro-1,4-Naphthoquinone
1H-吡唑-1-甲脒盐酸盐置于diea体系中,用 氯仿 用作溶剂,化学反应生成2-氨基-3-氯-1,4-萘醌
参考文献:Branched Cationic Lipids For Nucleic Acids Delivery System
标题:Branched Cationic Lipids For Nucleic Acids Delivery System
摘要:本发明涉及用于递送寡核苷酸的阳离子脂质以及利用纳米粒子组合物调节靶向基因表达的方法.具体而言,本发明涉及通过分支间隔物具有多个带正电性的衍生物的胆固醇及其衍生物,以及封装在阳离子脂质,融合脂质和peg脂质混合物中的寡核苷酸纳米粒子组合物.

海关参考信息

专利信息


专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
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✅ COA系统入驻 | 共享模式

主要参考文献


1: Svingen T, Ramhøj L, Mandrup K, Christiansen S, Axelstad M, Vinggaard AM, Hass U. Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides. Sci Rep. 2018 Jan 10;8(1):305. doi: 10.1038/s41598-017-18626-x.
2: Hass U, Christiansen S, Axelstad M, Scholze M, Boberg J. Combined exposure to low doses of pesticides causes decreased birth weights in rats. Reprod Toxicol. 2017 Sep;72:97-105. doi: 10.1016/j.reprotox.2017.05.004. Epub 2017 May 17. doi: 10.1021/es5039084. Epub 2014 Oct 23. doi: 10.3390/molecules18021973.
5: Nagai T, Ishihara S, Yokoyama A, Iwafune T. Effects of four rice paddy herbicides on algal cell viability and the relationship with population recovery. Environ Toxicol Chem. 2011 Aug;30(8):1898-905. doi: 10.1002/etc.582. Epub 2011 Jun 8. doi: 10.1111/j.1476-5381.2009.00223.x. Epub 2009 Apr 30.

合成参考文献


参考文献:10.1002/etc.582
摘要:Nagai T, Ishihara S, Yokoyama A, Iwafune T. Effects of four rice paddy herbicides on algal cell viability and the relationship with population recovery. Environ Toxicol Chem. 2011 Aug;30(8):1898–905. doi: 10.1002/etc.582.
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