CAS: 26198-65-2; (8S,16S)-3,12,21-Trihydroxy-2,10,14,22-Tetraoxo-3,9,15,21-Tetraazatricosane-8,12,16-Tricarboxylic Acid

📜枸橼酸叔-丁酯置于碳酸氢钠,N,N'-二环己基碳二亚胺,三氟乙酸体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 1.92H,反应生成3-[[(1S)-5-(乙酰基-羟基-氨基)-1-羧基-戊基]氨基甲酰]-2-[[(1S)-5-(乙酰基-羟基-氨基)-1-羧基-戊基]氨基甲酰甲基]-2-羟基-丙酸
参考文献:Utilizing An Iron(III)-Chelation Masking Strategy To Prepare Mono-And Bis-Functionalized Aerobactin Analogues For Targeting Pathogenic Bacteria
标题:Utilizing An Iron(III)-Chelation Masking Strategy To Prepare Mono-And Bis-Functionalized Aerobactin Analogues For Targeting Pathogenic Bacteria
摘要:我们提出了一种简便的方法,通过fe(III)螯合掩蔽策略对天然铁载体进行功能化,以制备荧光染料共轭物,用于针对致病菌的靶向.
Doi:10.1039/c7Cc05197B

专利信息

专利号:US-5739395-A
优先权日:1997-01-10
标题 :Method for synthesis of rhizoferrin
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:A method of synthesizing rhizoferrin and analogues thereof comprising acylating a protected polyamine with a citric acid diester; hydrolyzing the resulting amide to produce an N-protected rhizoferrin or analog thereof; and de-protecting the intermediate to produce rhizoferrin or the analog thereof.

专利号:EP-0500699-B1
优先权日:1989-11-03
标题 :Cross-protective salmonella vaccines
发明人：CURTISS ROY III; MUNSON MARYANN
权利人:UNIV WASHINGTON
摘要:Vaccines are provided for treatment of individuals for infections by gram negative bacteria. The vaccines are comprised of live avirulent Salmonella which are able to induce immunity to homologous and to heterologous Salmonella serotypes, and to other gram-negative enteric bacteria. The Salmonella of which the vaccine is comprised possess at least one mutation in a gene which globally regulates other genes, and which also possess a mutation in at least one other of the following type: a mutation either in a gene encoding an enzyme in a lipopolysaccharide synthesis, which results in a reversibly rough phenotype; or in a gene which regulates the synthesis of iron-regulated OMPs, such that the mutation leads to constitutive expression of these proteins. Strains useful for the production of these vaccines are also provided.

专利号:CA-2276598-C
优先权日:1997-01-10
标 题:Method for synthesis of rhizoferrin

专利号:WO-2010094587-A1
优先权日:2009-02-18
标 题:Microbial siderophore synthesis
发明人：WEBER THOMAS; BONGAERTS JOHANNES; EVERS STEFAN; MAURER KARL-HEINZ
权利人:HENKEL AG & CO KGAA; WEBER THOMAS; BONGAERTS JOHANNES; EVERS STEFAN; MAURER KARL-HEINZ
摘要:The product yield for siderophores in a microbial fermentation is improved if the fermented microorganisms have a reduced expression of the fur gene, in particular if the fermentation does not occur under a lack of iron.

专利号:WO-9830534-A1
优先权日:1997-01-10
标题 :Method for synthesis of rhizoferrin

专利号:EP-0973726-B1
优先权日:1997-01-10
标题 :Method for synthesis of rhizoferrin