CAS: 216502-94-2; Benzyl 3-(Chlorocarbonyl)Piperidine-1-Carboxylate

该化合物是一种化学化合物,其结构复杂,包括四氢环和苯基组.氯碳基功能组的存在表明,它可以参与核生殖性乙酰替代反应,使其在有机合成中有可能成为反应性化合物.由于酯和碳基功能的存在,可能影响其溶解于各种溶剂,这种化合物可能表现出中度至高度的极分.此外,四氢基会产生基本特性,使其得以参与各种化学反应,包括涉及电极的反应.该化合物的分子结构表明,由于含有氯和碳基化合物的化合物往往存在于生物活性分子中,因此有可能在医药化学中,特别是在药物的开发中应用.应当注意安全和处理预防措施,因为含有氯和碳基化合物的化合物可能会对健康和环境造成危害.

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上下游产品

CAS号78190-11-1 (|R|)-N-Cbz-3-哌啶甲酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号498-95-3 3-哌啶甲酸

合成工艺路线路线简述

    📜3-哌啶甲酸置于sodium Hydroxide,草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷,水 用作溶剂,化学反应生成1-苄氧羰基哌啶-3-甲酰氯
    参考文献:Ccr5 Antagonists As Anti-Hiv-1 Agents. Part 3: Synthesis And Biological Evaluation Of Piperidine-4-Carboxamide Derivatives
    标题:Ccr5 Antagonists As Anti-Hiv-1 Agents. Part 3: Synthesis And Biological Evaluation Of Piperidine-4-Carboxamide Derivatives
    摘要:Replacement Of The 5-Oxopyrrolidin-3-Yl Fragment In The Previously Reported Lead Structure With A 1-Acetylpiperidin-4-Yl Group Led To The Discovery Of A Novel Series Of Potent Ccr5 Antagonists. Introduction Of Small Hydrophobic Substituents On The Central Phenyl Ring Increased The Binding Affinity,Providing Low To Sub-Nanomolar Ccr5 Antagonists. The Selected Compound 11F Showed Excellent Antiviral Activity Against Ccr5-Using Hiv-1 Replication In Human Peripheral Blood Mononuclear Cells (Ec50 = 0.59 Nm) And An Acceptable Pharmacokinetic Profile In Dogs. (C) 2004 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmc.2004.10.013

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    主要参考文献

    参考标题:Synergistic Visible-Light Photoredox/nickel-Catalyzed Synthesis Of Aliphatic Ketones Via N-C Cleavage Of Imides
    作者:Javad Amani,Rauful Alam,Shorouk Badir,Gary A. Molander |发布日期:2017.5.5
    摘要:An Electrophilic, Imide-Based, Visible-Light-Promoted Photoredox/ni-Catalyzed Cross-Coupling Reaction For The Synthesis Of Aliphatic Ketones Has Been Developed. This Protocol Proceeds Through N-C(O) Bond Activation, Made Possible Through The Lower Activation Energy For Metal Insertion Into This Bond Due To Delocalization Of The Lone Pair Of Electrons On The Nitrogen By Electron-Withdrawing Groups.

    合成参考文献

    参考DOI号:10.1016/S0968-0896(98)00083-2
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