CAS: 204521-63-1; Palm-Glu(Nhs)-Otbu

相似化合物

1188328-22-4 32886-55-8 843666-26-2

上下游产品

N-(1-氧代十六烷基)-L-谷氨酸叔丁酯 (S)-5-(Tert-Butoxy)-5-Oxo-4-Palmitamidopentanoic Acid 536721-25-2
棕榈酸 N-羟基琥珀酰亚胺酯 Palmitic Acid N-Succinimide Ester 14464-31-4

棕榈酸 N-羟基琥珀酰亚胺酯置于碳酸氢钠,三乙胺体系中,用 四氢呋喃,水,二甲基亚砜 用作溶剂,化学反应 2.0H,反应生成(2S)-5-[(2,5-二氧代-1-吡咯烷基)氧基]-5-氧代-2-[(1-氧代十六烷基)氨基]戊酸叔丁酯
参考文献: Insulin Dimer-Incretin Conjugates[fr] Conjugués Dimères D'Insuline-Incrétine
标题: Insulin Dimer-Incretin Conjugates[fr] Conjugués Dimères D'Insuline-Incrétine
摘要:已披露将胰岛素二聚体与至少具有一种胰岛素增效活性的肽共轭化.

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:WO-2025078040-A1
优先权日:2023-10-09
标 题 :Lysine salt and method of manufacturing a lysine derivative
发明人：HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÃœEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÃœMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS
权利人:BACHEM HOLDING AG
摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.

专利号:EP-3819308-A1
优先权日:2019-11-07
标 题:Process for the manufacture of derivatized amino acids
发明人：RICCI ANTONIO; CALLENS ROLAND; NUIJENS TIMO; CABRI WALTER
权利人:FRESENIUS KABI IPSUM S R L
摘要:The present invention relates to peptide synthesis, and in particular to a process for the manufacture of protected amino acids substituted at their side-chains. In addition, the present invention relates to the use of such protected amino acids in the preparation of GLP-1 analogues, such as for instance liraglutide and semaglutide.

专利号:US-2018057558-A1
优先权日:2014-09-23
标题 :Synthesis of GLP-1 Peptides

专利号:CN-113150108-A
优先权日:2021-05-21
标 题 :A kind of solid-phase synthesis method of liraglutide

专利号:CN-113150108-B
优先权日:2021-05-21
标 题:A kind of solid-phase synthesis method of liraglutide