CAS: 192329-42-3; (S)-N-Hydroxy-2,2-Dimethyl-4-((4-(Pyridin-4-Yloxy)Phenyl)Sulfonyl)Thiomorpholine-3-Carboxamide

上下游产品

2H,6H-噁唑并[5,4,3-Ij]喹啉-2-酮,6-丁基-7-羟基-8,9-二(1-甲基乙氧基)- (3S)-2,2-Dimethyl-4-(4-Pyridin-4-Yloxyphenyl)Sulfonylthiomorpholine-3-Carboxylic Acid 192329-83-2

📜2H,6H-噁唑并[5,4,3-Ij]喹啉-2-酮,6-丁基-7-羟基-8,9-二(1-甲基乙氧基)-以70的收率获得(S)-2-[(羟基氨基)甲基]-5,6-二甲基-4-(4-吡啶-4-基氧苯基)磺酰基吗啉-3-硫酮
参考文献: Metalloproteinase Inhibitors,Pharmaceutical Compositions Containing Them And Their Pharmaceutical Uses,And Methods And Intermediates Useful For Their Preparation[fr] Inhibiteurs De Metalloproteinases,Compositions Pharmaceutiques Contenant Ces Inhibiteurs Et Leurs Utilisations Pharmaceutiques,Et Procedes Et Intermediaires Servant A Leur Preparation
标题: Metalloproteinase Inhibitors,Pharmaceutical Compositions Containing Them And Their Pharmaceutical Uses,And Methods And Intermediates Useful For Their Preparation[fr] Inhibiteurs De Metalloproteinases,Compositions Pharmaceutiques Contenant Ces Inhibiteurs Et Leurs Utilisations Pharmaceutiques,Et Procedes Et Intermediaires Servant A Leur Preparation
摘要:本发明涉及式(1)的化合物,其中:Z为o或s;V为二价基团,与c*和n一起形成一个具有六个环原子的环,其中除c*和n之外的每个环原子独立地未取代或被适当取代物取代,且其中至少一个其他环原子是从o,N和s中选择的杂原子,其余为碳原子;Ar为芳基或杂芳基;以及其药学上可接受的前药,盐和溶剂化物.本发明还涉及这些化合物的药学上可接受的前药,盐和溶剂化物.本发明还涉及通过给予式(1)的化合物或其前药,盐或溶剂化物来抑制金属蛋白酶活性的方法.本发明还涉及包含这些化合物,前药,盐和溶剂化物的有效量的药物组合物.本发明还涉及用于制备这些化合物,前药,盐和溶剂化物的有用方法和中间体.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-7022846-B2
优先权日:2002-06-10
标 题 :Metabolites of prinomastat and their synthesis
发明人：OUELLETTE MICHAEL A; POTTS BARBARA C M; SRIRANGAM JAYARAM K; TIBBETTS ANTHONY R; ZHANG KANYIN E
权利人:AGOURON PHARMA
摘要:Metabolites of a matrix metalloproteinase inhibitor prinomastat and their synthesis. These metabolites are: (3S)-N-hydroxy-4-(4-((1-oxy-pyrid-4-yl)oxy)benzenesulfonyl)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxamide (M6); (3S)-2,2-dimethyl-1,1-dioxo-4-[4-(1-oxy-pyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M7); (3S)-2,2-dimethyl-4-[4-(1-oxypyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M8); (3S)-2,2-dimethyl-1,1-dioxo-4-[4-(pyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M2); and (3S)-2,2-dimethyl-4-[4-(pyridin-4yloxy)-benzenesulfonyl)-thiomorphpline-3-carboxylic acid amide (M3).

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound

专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound