CAS: 1515-72-6; 2-Butylisoindoline-1,3-Dione

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CAS号109-65-9 正溴丁烷 | CAS号610-97-9 邻碘苯甲酸甲酯 | CAS号111-36-4 异氰酸正丁酯 | CAS号5394-18-3 N-(4-溴丁基)邻苯二甲酰亚胺 | CAS号18717-72-1 NORC°CAINE | CAS号201230-82-2 carbon monoxide | CAS号2782-40-3 Benzamide, N-butyl | CAS号85-44-9 苯酐 | CAS号109-73-9 正丁胺 | CAS号109-73-9 正丁胺 | CAS号50707-36-3 2-butyl-3H-isoi... | CAS号6299-97-4 2-butyl-2-methy...

邻苯二甲酸单乙酯置于benzotriazol-1-Yloxyl-Tris-(Pyrrolidino)-Phosphonium Hexafluorophosphate,对甲苯磺酸,N,N-二异丙基乙胺体系中,用 四氢呋喃 用作溶剂,化学反应 12.67H,反应生成N-正丁基邻苯二甲酰亚胺
参考文献:A Mild,Selective,Pybop Mediated Procedure For The Conversion Of Primary Amines Into Phthalimides
标题:A Mild,Selective,Pybop Mediated Procedure For The Conversion Of Primary Amines Into Phthalimides
摘要:
Doi:10.1055/s-1998-2038

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-8415510-B2
优先权日:2008-02-28
标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

专利号:US-2007282078-A1
优先权日:2006-06-01
标题:Synthesis of aryl N-acylurea from aryl isocyanates or aryl carbodiimides for use as intermediate in novel sequential self-repetitive reaction (SSRR) to form amides, amide-imides and their polymers
发明人：DAI SHENGHONG A; LIN JIANG-JEN; WEI KUAN-LIANG; WU CHIH-HENG; HUANG WEI-HSIANG
权利人:DAI SHENGHONG A; LIN JIANG-JEN; WEI KUAN-LIANG; WU CHIH-HENG; HUANG WEI-HSIANG
摘要:Disclosed is a process for synthesizing an aryl N-acylurea in both high selectivity and high yield, comprising reacting an aryl carbodiimide with a carboxylic acid under mild conditions. Thermolysis of N-acylureas at above about 120° C. gives amides and isocyanates, and the latter will undergo the repetitive reaction sequences in the presence of a carbodiimide catalyst. Based on this unique model, a sequential self-repetitive reaction (SSRR) is also developed in a versatile manner for converting aryl carbodiimides into amides, polyamides, polyamide-imides and polyamide-imide elastomers.

专利号:US-5104944-A
优先权日:1989-07-18
标题:Process for nucleophilic derivatization of materials having an imide group conjugated to an aromatic moiety
发明人：GOLDBERG MARTIN J; MORRIS DANIEL P; VIEHBECK ALFRED
权利人:IBM
摘要:A process for the synthesis of derivatives of materials containing an imide group conjugated to an aromatic moiety to form an ester, a thioester, an amide, a ketone, and silylesters. Electrons are supplied to redox sites to form a reduced imide material. The reduced imide material is contacted with a nucleophile which opens the imide ring of the reduced imide and chemically combines with a carbonyl carbon atom of the open imide ring to form an imide derivative.

专利号:US-12145139-B2
优先权日:2016-02-09
标题 :Manganese based complexes and uses thereof for homogeneous catalysis
发明人：MILSTEIN DAVID; NERUSH ALEX; VOGT MATTHIAS; MUKHERJEE ARUP; ESPINOSA-JALAPA NOEL ANGEL; CHAKRABORTY SUBRATA
权利人:YEDA RES & DEV; NERUSH ARKADI
摘要:The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

专利号:US-2008064867-A1
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides