CAS: 1513-65-1; 2,6-Difluoropyridine

相似化合物

372-48-5 3512-17-2 685517-71-9

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CAS号110-86-1 吡啶 | CAS号2402-78-0 2,6-二氯吡啶 | CAS号141-86-6 2,6-二氨基吡啶 | CAS号685517-67-3 2,6-二氟-3-碘吡啶 | CAS号109-09-1 2-氯吡啶 | CAS号2893-33-6 2,6-吡啶二甲腈 | CAS号3939-15-9 6-氟-2-氰基吡啶 | CAS号180606-17-1 2-氟-6-苯基吡啶 | CAS号171178-50-0 2,6-二氟烟酸 | CAS号920036-27-7 1-(2,6-二氟吡啶-3-基)乙酮 | CAS号223514-16-7 1-(6-氟吡啶-2-基)哌嗪 | CAS号80392-79-6 3-溴-2,6-二氟吡啶 | CAS号58602-02-1 2,6-二氟-3-硝基吡啶 | CAS号685517-67-3 2,6-二氟-3-碘吡啶 | CAS号128583-07-3 6-fluoropyridin...

2,6-二氯吡啶置于四甲基氟化铵体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,以95%的收率获得2,6-二氟吡啶
参考文献:室温s N Ar氟化的无水四甲基氟化铵
标题:室温s N Ar氟化的无水四甲基氟化铵
摘要:本文介绍了使用无水四甲基氟化铵(nme 4 F)在室温下对芳基卤化物和硝基芳烃进行s N Ar氟化.该试剂在温和的条件下(通常在室温下)有效地将芳基-X(x = Cl,Br,I,No 2,Otf)转化为芳基-F.该反应的底物包括缺电子的杂芳族化合物(22个实例)和芳烃(5个实例).反应的相对速率随x以及底物的结构而变化.但是,一般而言,带有x = No 2的基材或br反应最快.在所检查的所有情况下,这些反应的收率均与在升高的温度(即,更传统的卤代氟化条件)下使用csf所获得的收率相当或更好.反应还提供了可比较的产量,规模从100 Mg到10 G不等.进行了成本分析,结果表明,使用nme 4 F进行氟化处理通常比使用csf进行氟化处理更具成本效益.
Doi:10.1021/acs.Joc.5B02075

专利信息

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:WO-2025017286-A1
优先权日:2023-07-14
标 题 :Novel synthesis of colloidal quantum dot ink and applications in semiconductor devices
发明人：VASHISHTHA PARTH; HE XIN; MEHTA JOSHUA; LIU JUNPENG; VO CONG-DUAN
权利人:QUANTUM SCIENCE LTD
摘要:The present invention provides a method for producing a nanocrystal composition comprising an inorganic ligand via a one-pot synthesis. The present invention also provides nanocrystals comprising novel inorganic ligands and the use of these nanocrystals. The present invention further provides the use of the novel inorganic ligands in the preparation of nanocrystals.

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-7176336-B2
优先权日:2003-10-09
标题 :Process for the synthesis of unsaturated alcohols
发明人：MAUGHON BOB R; BURDETT KENNETH A; LYSENKO ZENON
权利人:DOW GLOBAL TECHNOLOGIES INC
摘要:A process of preparing an unsaturated alcohol (olefin alcohol), such as, a homo-allylic mono-alcohol or homo-allylic polyol, involving protecting a hydroxy-substituted unsaturated fatty acid or fatty acid ester, such as methyl ricinoleate, derived from a seed oil, to form a hydroxy-protected unsaturated fatty acid or fatty acid ester; homo-metathesizing or cross-metathesizing the hydroxy-protected unsaturated fatty acid or fatty acid ester to produce a product mixture containing a hydroxy-protected unsaturated metathesis product; and deprotecting the hydroxy-protected unsaturated metathesis product under conditions sufficient to prepare the unsaturated alcohol. Preferably, methyl ricinoleate is converted by cross-metathesis or homo-metathesis into the homo-allylic mono-alcohol 1-decene-4-ol or the homo-allylic polyol 9-octadecene-7,12-diol, respectively.

专利号:WO-2020118597-A1
优先权日:2018-12-13
标 题 :Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
权利人:INTERVET INT BV; INTERVET INC; CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
摘要:New processes for the preparation of 1- [ (3R, 4S) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide (I) which include (i) novel more efficient synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a novel pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).