CAS: 1425381-60-7; 2-(1-(4-((4-(4-Hydroxypiperidin-1-yl)Phenyl)Amino)-5-Oxo-5,6-Dihydropyrimido[4,5-D]Pyridazin-2-yl)Piperidin-4-yl)Acetonitrile

📜1-(4-氨基苯基)-4-羟基哌啶,置于1-(4-氨基苯基)-4-羟基哌啶体系中,化学反应生成化合物gusacitinib
参考文献:Pyrimido-Pyridazinone Compounds And Methods Of Use Thereof
标题:Pyrimido-Pyridazinone Compounds And Methods Of Use Thereof
摘要:本申请提供了新型嘧啶并吡啶嗪酮化合物以及制备和使用这些化合物的方法.通过向患者投药一种或多种化合物,这些化合物可用于治疗患者的炎症.在一种实施方式中,新型嘧啶并吡啶嗪酮化合物为公式(i)中的化合物,其中r1和r2在此定义.

专利信息

专利号:US-2022170057-A1
优先权日:2019-04-11
标题:Microorganisms and methods for the fermentation of cannabinoids
发明人：SZAMECZ BELA KRISZTIAN; VARSZEGI SZILVIA; NEMETH ATTILA; SZABO LORAND
权利人:ELESZTO GENETIKA INC
摘要:Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ 9 -tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBGA), Δ 9 -tetrahydrocannabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), Δ 9 -tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBC A synthase (CBCAS), HMG-Co reductase (HMG1), and/or famesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.