CAS: 141-24-2; (R,Z)-Methyl 12-Hydroxyoctadec-9-Enoate

上下游产品

methanol Ricinoleic acid heptanal Methyl 10-undecenoateazelaic acid heptanal Methyl 10-undecenoate °Ctadec-9-ene-1,12-diol

📜蓖麻油酸 以 甲醇 用作溶剂,化学反应生成蓖麻油酸甲酯
参考文献:Polymeric Formulations For Drug Delivery
标题:Polymeric Formulations For Drug Delivery
摘要:本文公开了由蓖麻油酸和天然脂肪二酸形成的聚酯酸酐或聚酯以及它们的制备方法,以及它们用于输送生物活性剂,包括小分子药物,肽和蛋白质,Dna和带阳离子脂质或聚合物或纳米和微粒子的dna复合物.这些药物输送组合物以液态形式给患者使用,在体内粘度增加形成药物库或植入物,并能够持续释放所包含的生物活性剂达数周之久.在首选实施例中,药物输送配方通过注射给予.在一个实施例中,该组合物适用于将药物局部或区域性输送到疾病部位,例如治疗实体肿瘤和骨感染.在首选实施例中,药物输送组合物适用于针对实体肿瘤的特定部位化疗,包括头颈鳞状细胞癌(scc),前列腺癌和肉瘤的肿瘤内注射或插入.

专利信息

专利号:US-2014194584-A1
优先权日:2013-01-07
标题 :Process for the synthesis of w-Unsaturated nitrile-acid/ester in which two types of cross metathesis are alternated consecutively swing process
发明人：DUBOIS JEAN-LUC; COUTURIER JEAN-LUC
权利人:ARKEMA FRANCE
摘要:The invention relates to a process for the synthesis of a monounsaturated nitrile-ester (acid) by cross metathesis starting from an unsaturated compound I comprising at least one trivalent nitrile, acid or ester functional group, characterized in that it comprises a stage in which two types of cross metathesis are alternated consecutively:n a first type of cross metathesis cm1 with an acrylic compound II chosen from acrylonitrile, acrylic acid or an acrylic ester, one of the compounds I or II comprising a nitrile functional group and the other of these compounds II or I comprising an acid or ester functional group, and a second type of cross metathesis cm2 with a light C 2 to C 4 alkene compound III, preferably with ethylene. nn The invention also relates to a process for the synthesis of an α,ω-amino ester (acid) obtained by a process comprising a stage in which the two types of cross metathesis defined above are alternated consecutively, followed by a hydrogenation stage.

专利号:US-8642792-B2
优先权日:2007-02-15
标题 :Method for the synthesis of omega-amino-alkanoic acids
发明人：DUBOIS JEAN-LUC
权利人:DUBOIS JEAN-LUC; ARKEMA FRANCE
摘要:The invention relates to a method for the synthesis of amino acids/esters of general formula NH 2 —(CH 2 ) n —COOR in which n is an integer between 5 and 14, and R is either H or an alkyl radical including from 1 to 4 carbon atoms, from natural long-chain mono-unsaturated fatty acids or esters including at least 10 adjacent carbon atoms per molecule, said method comprising: first converting, if necessary, said natural long-chain fatty acid or ester into a monounsaturated fatty acid/ester of general formula R 1 —(CH 2 ) m —CHâ•?CH—(CH 2 ) p —COOR in which R 1 is H, CH 3 or a COOR radical, m is an integer between 0 and 14 and p is an integer between 2 and 11, then submitting the latter to a crossed catalytic metathesis reaction with a compound of formula R 2 —CHâ•?CH—R 3 in which R 2 is either H or CN and R 3 is CN or CH 2 NH 2 , provided that if R 2 is CN, R 3 can be only CN, and finally converting the resulting product of the general formula R 3 —CHâ•?CH—(CH 2 ) p —COOR into an amino-acid, either by hydrogenation, or by hydrogenation of the trple terminal bond, or by amination of the double terminal bond.

专利号:US-8647848-B2
优先权日:2008-06-13
标题:Enzymatic synthesis of sphingolipids
发明人：HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

专利号:US-9567293-B2
优先权日:2013-02-08
标题 :Combined synthesis of a nitrile-ester/acid and of a diester/diacid
发明人：DUBOIS JEAN-LUC; COUTURIER JEAN-LUC; BRANDHORST MARKUS
权利人:ARKEMA FRANCE
摘要:A method for the combined synthesis of a mono-unsaturated nitrile-ester(acid) and of a bi-functional carbonyl compound, wherein it includes a step including the cross metathesis mc1 of an unsaturated fatty acid/ester compound with an unsaturated nitrile compound, in which mc1 is performed with partial conversion such as to obtain and recover, separately, at least the following products: a mono-unsaturated nitrile-ester/acid and a symmetrical compound, diester or diacid respectively including a double bond located in the middle of the molecular chain of compound, and subsequently a step including the oxidation cleavage cp2 of the double bond of compound, such as to form a single type of carbonyl compound having formula R2-(CH2)n-COR′, in which R′ is H or OH, depending on the operating conditions selected for the oxidation cleavage cp2. Also, the production of monomers for the polymer industry.

专利号:US-8835661-B2
优先权日:2011-08-26
标 题:Process for the synthesis of C11 and C12 omega-aminoalkanoic acid esters comprising a nitrilation step
发明人：COUTURIER JEAN-LUC; DUBOIS JEAN-LUC
权利人:COUTURIER JEAN-LUC; DUBOIS JEAN-LUC; ARKEMA FRANCE
摘要:A process for the synthesis of C11 and C12 ω-amino-alkanoic acid esters including a step of continuous nitrilation in the gas phase or in a mixed gas-liquid phase, a step of metathesis and a step of reduction by hydrogenation, using, as raw material, C10 and C11 ω-alkenoic acid esters.

专利号:US-8940923-B2
优先权日:2007-06-13
标题:Method for the synthesis of diacids or diesters from natural fatty acids and/or esters
发明人：DUBOIS JEAN-LUC
权利人:ARKEMA FRANCE
摘要:Disclosed herein a process for the synthesis of diacids or diesters of general formula ROOC—(CH 2 )x-COOR, in which n represents an integer between 5 and 14 and R is either H or an alkyl radical of 1 to 4 carbon atoms, starting from long-chain natural monounsaturated fatty acids or esters comprising at least 10 adjacent carbon atoms per molecule, of formula CH 3 —(CH 2 )n-CHR 1 —CH 2 —CHâ•?CH—(CH 2 )p-COOR, in which R represents H or an alkyl radical comprising from 1 to 4 carbon atoms, R 1 is either H or OH, and n and p, which are identical or different, are indices between 2 and 11.