CAS: 137081-41-5; 1-Fluorocyclopropanecarboxylic Acid

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154985-93-0 167073-07-6 127199-14-8

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CAS号63141-10-6 1-氟环丙基甲基酮

1-氨基环丙烷羧酸置于triethylamine Tris(Hydrogen Fluoride),Sodium Nitrite体系中,化学反应 10.0H,以38%的收率获得1-氟环丙烷羧酸
参考文献:一种1-氟环丙烷羧酸的制备方法
标题:一种1-氟环丙烷羧酸的制备方法
摘要:本发明公开了一种1‑氟环丙烷羧酸的制备方法,包括:将1‑氨基环丙烷羧酸溶于氟化试剂中,加入重氮化试剂,在反应温度‑78oc~150oc下,反应8~36H,得到1‑氟环丙烷羧酸.本发明的1‑氟环丙烷羧酸的制备方法,通过1‑氨基环丙烷羧酸与重氮化试剂反应,发生重氮化并与氟化试剂反应,通过简单的一步工艺,快速,高效地制备得到1‑氟环丙烷羧酸;使用1‑氨基环丙烷羧酸,氟化试剂,重氮化试剂作为原料,原料的成本低,反应条件易于控制,适于规模化生产;本发明的反应收率达到38%,工艺简单,不易造成污染.

专利信息

专利号:US-4555370-A
优先权日:1980-04-23
标题 :Process for the preparation of acyl cyanides
发明人：KLAUKE ERICH; FINDEISEN KURT
权利人:BAYER AG
摘要:A novel process for the preparation of acyl cyanides of the general formula R-CO-CN (I) wherein R represents an optionally substituted alkyl radical with 1 to 8 carbon atoms, an optionally substituted cycloalkyl radical with 3 to 12 carbon atoms, an optionally substituted aryl radical or an optionally substituted 5-membered or 6-membered heterocyclic radical, which can additionally be fused to a benzene ring, in which a carboxylic acid fluoride or the general formula R-CO-F (II) in which R has the abovementioned meaning is reacted with an alkali metal cyanide, optionally in the presence of a diluent, at a temperature between 10 DEG and 200 DEG C. The acylcyanides (I) can be used as intermediates in the synthesis of known herbicides.

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:WO-2025125811-A1
优先权日:2023-12-12
标题:Heterocyclic compounds and their use for the treatment of neurological disorders
发明人：PLOWRIGHT ALLEYN THOMAS; PFEIFFER THOMAS; MÄRCHER-RØRSTED EMIL; DUCKWORTH EDWARD JOSEPH
权利人:ONTRACK THERAPEUTICS LTD
摘要:The present invention relates to novel synthetic compounds of Formula (I) and (II) related to naturally occurring flavonoids such as 7,8-dihydroxyflavone (7,8-DHF). The invention further relates to the method of synthesis, the use of these compounds as research tools and their use as pharmaceuticals.

专利号:US-11267824-B2
优先权日:2017-08-17
标 题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
发明人：BOSS CHRISTOPH; BUR DANIEL; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.

专利号:US-11858943-B2
优先权日:2017-06-05
标题:Vasopressin receptor antagonists and products and methods related thereto
发明人：JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON
权利人:NEUMORA THERAPEUTICS INC
摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.

专利号:CN-116640043-A
优先权日:2023-04-24
标题:Synthesis method of 1-fluorocyclopropane carboxylic acid