CAS: 133-11-9; Phenyl 4-Amino-2-Hydroxybenzoate

该化合物是一种有机化合物,其特性是用硅酸盐和苯酚组成的酯功能组,其特性为:一种白色晶状固体,有轻微的芳香气味,一般在水中不溶解,但在乙醇和乙醇等有机溶剂中可溶解.这种化合物的特性使其在各种应用中有用,包括作为太阳屏中的紫外线过滤器和塑料稳定剂.此外,还研究过它的潜在治疗作用,特别是在其抗炎和厌食特性方面.分子结构是附于盐酸酸碱4位置的苯基组,有助于其化学反应和相互作用.由于其毒性相对较低,它常常被认为在化妆剂中使用安全,但应注意避免过度接触.总的来说,苯基4-氨酸盐酸盐是一种具有重大关联性的复合化合物,在工业和制药方面都具有重大关联性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号62350-74-7 phenyl 2-hydrox... | CAS号619-19-2 4-硝基水杨酸 | CAS号108-95-2 苯酚 | CAS号37987-05-6 2-acetoxy-4-ace... | CAS号65-49-6 对氨基水杨酸 | CAS号117869-04-2 2-hydroxy-4-sul... | CAS号39614-82-9 Benzoyl chlorid...

合成工艺路线路线简述

  • 合成目标产物 Phenyl-4-Aminosalicylate 主要起始原料 Phenol
  • (文献来源)合成步骤主要原料 Phenol
苯酚置于盐酸,溶剂黄146,锌,三氯氧磷体系中,化学反应生成非那米柳
参考文献:Studies On Antituberculotics. I. Preparation Of Aryl P-Aminosalicylates
标题:Studies On Antituberculotics. I. Preparation Of Aryl P-Aminosalicylates
摘要:
Doi:10.1021/ja01130A037

海关参考信息

专利信息


专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人:ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-9868747-B2
优先权日:2014-02-18
标题:Marinopyrrole derivatives and methods of making and using same
发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人:IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-6911318-B2
优先权日:1999-03-03
标 题:Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
发明人:KAHNE SUZANNE WALKER
权利人:UNIV PRINCETON
摘要:This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.
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合成参考文献


参考文献:10.1038/ncb3255
摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
摘要:https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b01709
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