CAS: 959237-68-4; 7-Bromo-2,4-Dichloroquinazoline

该化合物是一种卤化的五氯苯衍生物,在制药和农用化学研究方面有很大的用途.它独特的溴和氯替代成分增强了反应性,使其成为核生殖替代和交叉反应的多种中间体.该化合物的结构特征有利于合成更为复杂的七环系统,特别是在发展动脉抑制剂和其他生物活性分子方面.在标准条件下,它的高纯度和稳定性确保了合成应用的可靠性能.研究人员认为这种化合物具有持续的质量和药用化学的适应性,经常需要五氯联苯核心的精确功能化.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号114703-12-7 7-溴喹唑啉-2,4-二酮 | CAS号591-19-5 3-溴苯胺 | CAS号6326-79-0 6-溴靛红 | CAS号65971-74-6 N-(3-bromopheny... | CAS号20776-50-5 2-氨基-4-溴苯甲酸 | CAS号135484-83-2 2-氨基-4-溴苯甲酸甲酯

合成工艺路线路线简述

  • 114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; Rt; 4 H,100 °C1.2 Reagents: Water; 0 °C
    标题:Preparation Of Nucleotides As Cd73 Inhibitors
    参考文献:World Intellectual Property Organization]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; Rt; 36 H,Reflux
    标题:Morpholinylquinazolines As Dna-Pk Inhibitors And Their Preparation And Use In The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    304858-65-9 = 959237-68-4
    反应条件:1.1 Reagents: Triethylamine,Triphenylphosphine Oxide Solvents: Chlorobenzene; 0 °C; 0.5 H,Rt1.2 5 H,120 °C; Cooled; 18 H,Rt
    标题:Preparation Of Quinazoline Derivatives And Their Use In The Treatment Of Ocular Disorders
    参考文献:World Intellectual Property Organization]

    304858-65-9 = 959237-68-4
    反应条件:1.1 Reagents: Triethylamine,Triphenylphosphine Oxide Solvents: Chlorobenzene; 0 °C; 0.5 H,Rt1.2 5 H,120 °C; Cooled; 18 H,Rt
    标题:Preparation Of Functionalized Quinazoline Compounds As Heparanase Inhibitors And Use Thereof
    参考文献:World Intellectual Property Organization]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; 12 H,130 °C
    标题:Preparation Of Substituted 5-(Quinazolin-2-Yl)Pyrimidin-2-Amine Derivatives Useful As Pi3K/mtor Inhibitors For The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    = 959237-68-4 [标题:Reaction Conditions
    标题:An Allosteric Modulator Binds To A Conformational Hub In The β2 Adrenergic Receptor
    作者:Liu,Xiangyu; Kaindl,Jonas; Korczynska,Magdalena; Stossel,Anne; Dengler,Daniela; Et Al
    参考文献:Nature Chemical Biology 日期:2020 卷标:16(7) 页码:749-755]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: N,N-Diethylaniline,Phosphorus Oxychloride; 4 H,Reflux
    标题:Discovery And Sar Of A Novel Series Of Natriuretic Peptide Receptor-A (Npr-A) Agonists
    作者:Iwaki,Takehiko; Nakamura,Yuji; Tanaka,Taisaku; Ogawa,Yasuyuki; Iwamoto,Osamu; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2017 卷标:27(21) 页码:4904-4907]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; 4 H,Reflux1.2 Reagents: Water; Cooled
    标题:Preparation Of Quinazoline Nucleotides As Cd73 Inhibitors
    参考文献:World Intellectual Property Organization]

    57-13-6 + 20776-50-5 = 959237-68-4
    反应条件:1.1 3 H,Rt -> 200 °C; 200 °C -> 80 °C1.2 Reagents: Water; 80 °C1.3 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; 4 H,120 °C
    标题:Synthesis,Inhibitory Activity And In Silico Modeling Of Selective Cox-1 Inhibitors With A Quinazoline Core
    作者:Dvorakova,Marcela; Langhansova,Lenka; Temml,Veronika; Pavicic,Antonio; Vanek,Tomas; Et Al
    参考文献:Acs Medicinal Chemistry Letters 日期:2021 卷标:12(4) 页码:610-616]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; 12 H,130 °C
    标题:Preparation Of Morpholinylheteroarylquinazolinylphenylcarbonylphenylurea Derivatives And Analogs For Use As Dual Pi3K/mtor Inhibitors
    参考文献:World Intellectual Property Organization]

    20776-48-1 + 57-13-6 = 959237-68-4
    反应条件:1.1 3 H,Rt -> 200 °C; Cooled1.2 Reagents: Water1.3 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; 6 - 24 H,Reflux; Cooled1.4 Reagents: Water; 0 °C
    标题:Preparation Of Quinazolinediamine Derivatives For Use As Antibiotics
    参考文献:United States]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride; 6 - 24 H,Reflux
    标题:Characterizing The Antimicrobial Activity Of N2,N4-Disubstituted Quinazoline-2,4-Diamines Toward Multidrug-Resistant Acinetobacter Baumannii
    作者:Fleeman,Renee; Van Horn,Kurt S.; Barber,Megan M.; Burda,Whittney N.; Flanigan,David L.; Et Al
    参考文献:Antimicrobial Agents And Chemotherapy 日期:2017 卷标:61(6)]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; 16 H,0 °C -> 110 °C1.2 Solvents: Water; 30 Min,Cooled
    标题:Triazoloquinazolines As Diacylglycerol Kinase Modulating Compounds And Their Preparation
    参考文献:World Intellectual Property Organization]

    114703-12-7 = 959237-68-4
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride; 4 H,100 °C; 100 °C -> Rt1.2 Reagents: Water; Rt
    标题:Heterocyclic Compounds As Prmt5 Inhibitors And Their Preparation
    参考文献:World Intellectual Property Organization
📜N-(3-Bromophenyl)-2-Hydroxyiminacetamide置于硫酸,双氧水,N,N-二异丙基乙胺,Sodium Hydroxide,三氯氧磷体系中,用 水 作为反应溶剂,化学反应 20.0H,反应生成 2,4-二氯-7-溴喹唑啉
参考文献: Substituted Quinazoline And Pyrido-Pyrimidine Derivatives[fr] Dérivés De Quinazoline Et De Pyrido-Pyrimidine Substituées
标题: Substituted Quinazoline And Pyrido-Pyrimidine Derivatives[fr] Dérivés De Quinazoline Et De Pyrido-Pyrimidine Substituées
摘要:本申请提供了新型的取代喹唑啉和吡啶并嘧啶化合物及其药用盐.还提供了制备这些化合物的方法.通过向患者投与一种或多种化合物的治疗有效量,这些化合物对于通过共同调节pi3K和/或mtor活性来治疗与pi3K/akt/mtor通路失调相关的疾病是有效的.这些化合物具有双重pi3K/mtor抑制剂的作用.这些化合物可用于治疗多种疾病,包括以炎症或异常细胞增殖为特征的疾病.在一个实施例中,该疾病是癌症.

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合成参考文献


参考文献:10.1007/s00044-026-03533-6
摘要:Ni D, Jin M, Zhou H, Xue R, Wu F, Pu T, Liang B, Zhang R, Su J, Xiao W. Discovery of quinazoline-based derivatives as novel autophagy inhibitors in pancreatic cancer. Med Chem Res. 2026 Feb 19;35(3):634–48. doi: 10.1007/s00044-026-03533-6.
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