CAS: 85-01-8; Phenanthrene
该化合物是一种多环芳烃(PAH),其特征是三根结合的苯环,形成一个泛芳香结构,在室内温度下是无色的晶状固态,有煤焦油的特有味性. 苯丙烯在水中是无法溶解的,但在苯,甲苯和氯仿等有机溶剂中是可溶解的.其分子式为C14H10,其分子重量约为178.23克/摩尔. 苯丙胺因其稳定性和耐氧化性而闻名,使其成为持久性的环境污染物,主要通过有机材料的不完全燃烧产生,在煤油和化石燃料中发现. 在应用方面,苯丙胺被用于生产染料,塑料和各种化学合成物的前体.然而,人们也认识到其潜在的健康风险,因为它被归类为一种可能的人类致癌物质,需要谨慎地处理和监管工业环境.
- 英文名称Phenanthrene
- 中文名称菲
- IUPAC名称Phenanthrene
- 其它别名Ravatite; [3]Helicene; Phenanthren; Phenanthren [German]; Phenanthrin; Ravatite; Phenanthrene, pure
- CAS编号85-01-8
- MFCD编号:MFCD00001168
- EINECS号:201-581-5
- FDA UNII编号:448J8E5BST
- 分子式:C14H10
- 分子量:178.23
- 产品CID: 2372808
- 产品分类有机原料→分子砌块→芳环类化合物→菲类化合物
相似化合物
24423-11-8 715-50-4 1262770-68-2物理性质
- 熔点98-100°C
- 沸点337.4°C at 760 mmHg
- 闪点99-101°C
- 密度690kg/m3
- pKa:>15 (Christensen et al., 1975)
- LogP:3.993
- 折射率1.5943
- 蒸汽压0.00012 hPa (20 °C)
- 溶解性Soluble In Alcohol, Benzene, Toluene, And Glacial Acetic Acid
- 敏感性PHENANTHRENE may react with oxidizing materials (NTP, 1992).
- 外观形态棕色薄片状晶体 (细)
- 储存条件室温
- 产品应用可用于合成树脂,植物生长激素,还原染料,鞣料等方面,菲经氢化制得全氢菲可用于生产喷气飞机的燃料.
- 性质描述白色有光泽并发荧光的片状晶体,能升华.不溶于水,稍溶于乙醇,能溶于乙醚,冰醋酸,苯,四氯化碳和二硫化碳等.溶液具有蓝色荧光.熔点100°C,沸点340°C(332°C),210-215°C(1.6kPa),相对密度0.9800(4/4°C),折射率1.5943,自燃点185°C.粉尘与空气混合能形成爆炸性混合物,爆炸限5.04g/m3(下限).
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
皮肤腐蚀/刺激 类别2
水生急性毒性 类别1
水生慢性毒性 类别1
皮肤致敏 类别1
特定目标器官毒性 - 单次接触 类别3
严重眼刺激 类别2
vPvB
致癌性 类别2
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
H317 |可能引起皮肤过敏反应.
H335 |可能引起呼吸道刺激.
H319 |造成严重眼刺激.
EUH441 |Strongly accumulates in the environment and living organisms including in humans
H351 |怀疑致癌. - 防范说明P264-P270-P273-P330-P391-P501
- 危险等级9
- UN编号3077.0
- 危险品标志Xn,N,F,T
- 包装等级Ⅲ
- 安全声明26-60-61-36/37-29-62-45-16-7-24/25-23-53-37/39-22-33-25-9
- 危险类别码22-36/37/38-50-50/53-40-67-65-38-11-52/53-39/23/24/25-23/24/25-63-43-45-20/21/22-20
- WGK Germany2.0
欧盟法规
REACH注册ECHA物质ECHA物质C&L通报REACH预注册欧盟候选物质清单上下游产品
1-benzofurane benzene n-butyl magnesium bromide phosgened,f][1,2]diox°Cin5,8-Dimethoxy-5,8-dihydro-dibenzo[d,f][1,2]diox°Cin 9-bromophenanthrene 2,2'-(phenanthrene-3,6-dicarbonyl)-di-benzoic acid 9-(chloromethyl)phenanthrene合成工艺路线路线简述
- 34919-47-6 = 85-01-8
反应条件:1.1 Catalysts: Grubbs' Catalyst; 8 H,25 °C
标题:Polycyclic Aromatic Hydrocarbons By Ring-Closing Metathesis
作者:Bonifacio,Margel C.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(21) 页码:8522-8526]
34919-47-6 = 85-01-8
反应条件:1.1 Catalysts: Grubbs Second Generation Catalyst Solvents: Dichloromethane; 24 H,20 °C
标题:Studies Towards The Total Synthesis Of Sch 56036; Isoquinolinone Synthesis And The Synthesis Of Phenanthrenes
作者:Walker,Edward R.; Et Al
参考文献:Tetrahedron Letters 日期:2005 卷标:46(38) 页码:6537-6540]
573-17-1 = 85-01-8
反应条件:1.1 Reagents: Ammonia,Diboronic Acid Catalysts: Palladium Solvents: Methanol,1,2-Dichloroethane; 1 H,50 °C
标题:Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations With Tetrahydroxydiboron And A Tertiary Amine
作者:Korvinson,Kirill A.; Et Al
参考文献:Advanced Synthesis & Catalysis 日期:2020 卷标:362(1) 页码:166-176]
573-17-1 = 85-01-8
反应条件:1.1 Reagents: Azobisisobutyronitrile,1,3-Bis(1,1-Dimethylethyl)Hexahydro-1,3,2-Diazaphosphorine Solvents: Toluene; 5 H,90 °C
标题:Exploiting The Radical Reactivity Of Diazaphosphinanes In Hydrodehalogenations And Cascade Cyclizations
作者:Zhang,Jingjing; Et Al
参考文献:Chemical Science 日期:2020 卷标:11(18) 页码:4786-4790]
82131-17-7 = 85-01-8
反应条件:1.1 Reagents: Aluminum Chloride
标题:A Convenient Reduction Of Functionalized Polycyclic Aromatics Into Parent Hydrocarbons
作者:Node,Manabu; Et Al
参考文献:Tetrahedron Letters 日期:1982 卷标:23(6) 页码:689-92]
90401-64-2 = 85-01-8
反应条件:1.1 Catalysts: Di-μ-Bromohexacarbonylbis(Tetrahydrofuran)Dirhenium Solvents: 1,2-Dichloroethane; 24 H,25 °C
标题:Indium-Catalyzed Construction Of Polycyclic Aromatic Hydrocarbon Skeletons Via Dehydration
作者:Kuninobu,Yoichiro; Et Al
参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(17) 页码:7005-7009]
5085-74-5 = 85-01-8
反应条件:1.1 Reagents: Methyldimethoxysilane Catalysts: Bis(1,5-Cyclooctadiene)Nickel,Tricyclohexylphosphine Solvents: Toluene; Rt; 12 H,80 °C; Cooled
标题:Nickel-Catalyzed Reductive Cleavage Of Aryl-Oxygen Bonds In Alkoxy- And Pivaloxyarenes Using Hydrosilanes As A Mild Reducing Agent
作者:Tobisu,Mamoru; Et Al
参考文献:Chemical Communications (Cambridge 日期:2011 卷标:47(10) 页码:2946-2948]
5085-74-5 = 85-01-8
反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Bis(1,5-Cyclooctadiene)Nickel,1H-Imidazolium,1,3-Bis(Tricyclo[3.3.1.13,7]Dec-2-Yl)-,Chloride (1:1) Solvents: Toluene; 3 Min,Rt1.2 Solvents: Toluene; 18 H,160 °C
标题:Nickel-Catalyzed Reductive Cleavage Of Aryl Alkyl Ethers To Arenes In Absence Of External Reductant
作者:Tobisu,Mamoru; Et Al
参考文献:Chemical Science 日期:2015 卷标:6(6) 页码:3410-3414]
103-30-0 = 85-01-8
反应条件:1.1 Reagents: Tetrahydrofuran,Iodine Solvents: Toluene,Tetrahydrofuran; 7 H,Rt
标题:Synthesis Of Derivatives Of Phenanthrene And Helicene By Improved Procedures Of Photocyclization Of Stilbenes
作者:Talele,Harish R.; Et Al
参考文献:Bulletin Of The Chemical Society Of Japan 日期:2009 卷标:82(9) 页码:1182-1186]
17533-18-5 = 85-01-8
反应条件:1.1 Solvents: Triethyl Phosphite
标题:Anomalous Reactions Of Diethyl Sodiophosphite And Triethyl Phosphite With Some Halogen Derivatives
作者:Arbuzov,B. A.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1954 卷标:837 页码:837-45]
27652-35-3 = 85-01-8
反应条件:1.1 Reagents: Sodium Carbonate,Tert-Butyl Nitrite Catalysts: Acridine Orange Base Solvents: Dimethyl Sulfoxide; 0 °C; 6 H,Rt
标题:Visible-Light-Mediated Synthesis Of Phenanthrenes Through Successive Photosensitization And Photoredox By A Single Organocatalyst
作者:Mandal,Tanumoy; Et Al
参考文献:Organic Letters 日期:2022 卷标:24(45) 页码:8452-8457]
2889541-69-7 = 85-01-8
反应条件:1.1 Catalysts: Bis(1,5-Cyclooctadiene)Nickel,1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene Solvents: Tetrahydrofuran; 48 H,Rt
标题:Catalytic Disproportionation Via Carbonate Redox Tags - A Unified Strategy For Mild Hydrogenolysis And Oxidations Of C-O Bonds
作者:Toupalas,Georgios; Et Al
参考文献:Chemrxiv 日期:2022 卷标:1 页码:1-29]
17024-12-3 = 85-01-8
反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Ferrous Chloride Solvents: Acetonitrile; 15 Min,Rt1.2 Solvents: Acetonitrile; 16 H,50 °C1.3 Reagents: Water; 15 Min,Rt
标题:Iron-Catalyzed Reductive Radical Cyclization Of Organic Halides In The Presence Of Nabh4: Evidence Of An Active Hydrido Iron(I) Catalyst
作者:Ekomie,Audrey; Et Al
参考文献:Angewandte Chemie 日期:2012 卷标:51(28) 页码:6942-6946]
4707-71-5 = 85-01-8
反应条件:1.1 Catalysts: Palladium Diacetate Solvents: Cyclohexane; 24 H,140 °C
标题:A General And Efficient Aldehyde Decarbonylation Reaction By Using A Palladium Catalyst
作者:Modak,Atanu; Et Al
参考文献:Chemical Communications (Cambridge 日期:2012 卷标:48(35) 页码:4253-4255]
56667-11-9 = 85-01-8
反应条件:1.1 Reagents: Hexamethylditin Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,4-Dioxane
标题:The Stille Reaction
作者:Farina,Vittorio; Et Al
参考文献:Organic Reactions (Hoboken 日期:1997 卷标:50]
56667-11-9 = 85-01-8
反应条件:1.1 Reagents: Hexamethylditin Catalysts: Tetrakis(Triphenylphosphine)Palladium
标题:Intramolecular Biaryl Coupling: Asymmetric Synthesis Of The Chiral B-Ring Diol Unit Of Pradimicinone
作者:Kelly,T. Ross; Et Al
参考文献:Tetrahedron Letters 日期:1990 卷标:31(2) 页码:161-4]
645-49-8 = 85-01-8
反应条件:1.1 Catalysts: Potassium Iodide Solvents: Hexane; 1.75 H
标题:Air-Driven Potassium Iodide-Mediated Oxidative Photocyclization Of Stilbene Derivatives
作者:Matsushima,Tomoya; Et Al
参考文献:Journal Of Organic Chemistry 日期:2016 卷标:81(17) 页码:7799-7806]
645-49-8 = 85-01-8
反应条件:1.1 Reagents: Diphenyl Diselenide,Oxygen Solvents: Cyclohexane
标题:Photocyclization Of Stilbenes And Related Molecules
作者:Mallory,Frank B.; Et Al
参考文献:Organic Reactions (Hoboken 日期:1984 卷标:30]
96447-43-7 = 85-01-8
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water
标题:The Ramberg-Backlund Rearrangement
作者:Paquette,Leo A.
参考文献:Organic Reactions (Hoboken 日期:1977 卷标:25]
96447-43-7 = 85-01-8
反应条件:1.1 Solvents: 1,4-Dioxane,Water
标题:α-Halo Sulfones. I. Conformational Requirements Of α-Sulfonyl Carbanions In The Synthesis Of Phenanthrenes From 2-Chloro-2,7-Dihydro-3,4,5,6-Dibenzothiepin 1,1-Dioxides
作者:Paquette,Leo A.
参考文献:Journal Of The American Chemical Society 日期:1964 卷标:86(19) 页码:4085-9]
34919-47-6 = 85-01-8
反应条件:1.1 Catalysts: Benzyltrimethylammonium Tribromide Solvents: Dichloromethane; 2 H,25 °C
标题:Ring-Closing Olefin Metathesis Of 2,2'-Divinylbiphenyls: A Novel And General Approach To Phenanthrenes
作者:Iuliano,Anna; Et Al
参考文献:Organic Letters 日期:2004 卷标:6(21) 页码:3711-3714]
573-17-1 = 85-01-8
反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Azobisisobutyronitrile Solvents: Acetonitrile; 5 H,80 °C
标题:Stannylated Vinylic Addition Polynorbornene: Probing A Reagent For Friendly Tin-Mediated Radical Processes
作者:Garcia-Loma,Rodrigo; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2017 卷标:2017(29) 页码:4247-4254]
82131-17-7 = 85-01-8
反应条件:1.1 Reagents: Aluminum Chloride Catalysts: Ethanethiol
标题:Hard Acid And Soft Nucleophile System. Vii. A Convenient Reduction Of Functionalized Polyarenes To Parent Polyarenes
作者:Node,Manabu; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1983 卷标:31(12) 页码:4306-11]
90401-64-2 = 85-01-8
反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: 1,1,1,3,3,3-Hexafluoro-2-Propanol; 20 Min,0 °C1.2 Solvents: Water; Ph 7
标题:Facile Synthesis Of Polycyclic Aromatic Hydrocarbons: Bronsted Acid Catalyzed Dehydrative Cycloaromatization Of Carbonyl Compounds In 1,1,1,3,3,3-Hexafluoropropan-2-Ol
作者:Fujita,Takeshi; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2017 卷标:2017(2) 页码:262-265]
90401-64-2 = 85-01-8
反应条件:1.1 Catalysts: Bismuth Triflate Solvents: 1,2-Dichloroethane; 2 H,25 °C
标题:Bismuth-Catalyzed Synthesis Of Polycyclic Aromatic Hydrocarbons (Pahs) With A Phenanthrene Backbone Via Cyclization And Aromatization Of 2-(2-Arylphenyl)Vinyl Ethers
作者:Murai,Masahito; Et Al
参考文献:Organic Letters 日期:2014 卷标:16(16) 页码:4134-4137]
= 85-01-8
反应条件:1.1 Catalysts: Cobalt(Ii) Acetylacetonate,1H-Imidazolium,1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-4,5-Dihydro-,Chloride (1:... Solvents: Tetrahydrofuran; 10 Min,Rt1.2 Reagents: Hexylmagnesium Bromide Solvents: Tetrahydrofuran; 12 H,70 °C
标题:Cobalt-Catalyzed Reduction Of Aryl Sulfones To Arenes By Means Of Alkylmagnesium Reagents
作者:Fukuda,Jun-Ichi; Et Al
参考文献:Asian Journal Of Organic Chemistry 日期:2018 卷标:7(10) 页码:2049-2052]
128531-54-4 = 85-01-8
反应条件:1.1 Reagents: Hexamethylditin Catalysts: Tetrakis(Triphenylphosphine)Palladium
标题:Intramolecular Biaryl Coupling: Asymmetric Synthesis Of The Chiral B-Ring Diol Unit Of Pradimicinone
作者:Kelly,T. Ross; Et Al
参考文献:Tetrahedron Letters 日期:1990 卷标:31(2) 页码:161-4]
5085-74-5 = 85-01-8
反应条件:1.1 Reagents: Aluminum Chloride
标题:A Convenient Reduction Of Functionalized Polycyclic Aromatics Into Parent Hydrocarbons
作者:Node,Manabu; Et Al
参考文献:Tetrahedron Letters 日期:1982 卷标:23(6) 页码:689-92]
103-30-0 = 85-01-8
反应条件:1.1 Reagents: Oxygen Catalysts: Iodine Solvents: Cyclohexane; 8 Min,Rt
标题:Efficient Synthetic Photocyclization For Phenacenes Using A Continuous Flow Reactor
作者:Okamoto,Hideki; Et Al
参考文献:Chemistry Letters 日期:2014 卷标:43(7) 页码:994-996]
103-30-0 = 85-01-8
反应条件:1.1 Reagents: Iodine Solvents: Toluene,Tetrahydrofuran; 2 H,Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water; Rt
标题:Continuous Flow Photocyclization Of Stilbenes - Scalable Synthesis Of Functionalized Phenanthrenes And Helicenes
作者:Lefebvre,Quentin; Et Al
参考文献:Beilstein Journal Of Organic Chemistry 日期:2013 卷标:9 页码:1883-1890]
2889541-69-7 = 85-01-8
反应条件:1.1 Catalysts: Bis(1,5-Cyclooctadiene)Nickel,1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene Solvents: Tetrahydrofuran; 48 H,Rt
标题:Ni-Catalyzed Mild Hydrogenolysis And Oxidations Of C-O Bonds Via Carbonate Redox Tags
作者:Toupalas,Georgios ; Et Al
参考文献:Nature Communications 日期:2023 卷标:14(1)]
66-71-7 = 85-01-8
反应条件:1.1 Solvents: Dimethylformamide; 4 H,90 °C
标题:Nickel-Catalyzed Synthesis Of Stereochemically Defined Enamides Via Bi- And Tricomponent Coupling Reaction
作者:Liu,Y.; Et Al
参考文献:Organic Letters 日期:2017 卷标:19(19) 页码:5034-5037]
776-35-2 = 85-01-8
反应条件:1.1 Reagents: Oxygen Catalysts: Molybdovanadophosphoric Acid (H5Pmo10V2O40) (Tetraglyme Complex) Solvents: 1,2-Dichloroethane
标题:Aromatization Of Hydrocarbons By Oxidative Dehydrogenation Catalyzed By The Mixed Addenda Heteropoly Acid H5Pmo10V2O40
作者:Neumann,Ronny; Et Al
参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(19) 页码:4607-10]
776-35-2 = 85-01-8
反应条件:1.1 Reagents: Graphite (Acidic,Graphite Oxide) Solvents: Chloroform; 24 H,100 °C; 100 °C -> Rt
标题:C-H Oxidation Using Graphite Oxide
作者:Jia,Hong-Peng; Et Al
参考文献:Tetrahedron 日期:2011 卷标:67(24) 页码:4431-4434]
83164-98-1 = 85-01-8
反应条件:1.1 Reagents: Chlorotrimethylsilane,Sodium Iodide Solvents: Acetonitrile
标题:Synthesis Of 1,4-,2,4-,And 3,4-Dimethylphenanthrenes: A Novel Deoxygenation Of Arene 1,4-Endoxides With Trimethylsilyl Iodide
作者:Jung,Kee Yong; Et Al
参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(24) 页码:5667-75]
83164-98-1 = 85-01-8 [标题:Reaction Conditions
标题:Deoxygenation Of 1,4-Epoxy-1,4-Dihydroarenes With Enneacarbonyldiiron
作者:Best,Wayne M.; Et Al
参考文献:Australian Journal Of Chemistry 日期:1982 卷标:35(4) 页码:843-8]
83164-98-1 = 85-01-8
反应条件:1.1 Reagents: Triphenyl Phosphite Catalysts: Rhenium Oxide (Re2O7) Solvents: Toluene; 18 H,80 °C
标题:Regioselective Arene Homologation Through Rhenium-Catalyzed Deoxygenative Aromatization Of 7-Oxabicyclo[2.2.1]Hepta-2,5-Dienes
作者:Murai,Masahito; Et Al
参考文献:Chemical Communications (Cambridge 日期:2019 卷标:55(16) 页码:2332-2335]
1416371-19-1 = 85-01-8
反应条件:1.1 Reagents: Lithium Tert-Butoxide,Water Catalysts: Cobalt Dibromide,1H-Imidazolium,1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-,Chloride (1:1) Solvents: Tetrahydrofuran; 6 H,80 °C; 80 °C -> Rt1.2 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Cobalt-Catalyzed Protodeboronation Of Aryl And Vinyl Boronates
作者:Li,Ninglin; Et Al
参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(2) 页码:1972-1979]
17024-12-3 = 85-01-8
反应条件:1.1 Reagents: Diisopropylethylamine Catalysts: Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-κn1,κn1′]Bis[2-(2-Pyri... Solvents: Acetonitrile; 25 °C
标题:Visible-Light-Induced Photocatalytic Reductive Transformations Of Organohalides
作者:Kim,Hyejin; Et Al
参考文献:Angewandte Chemie 日期:2012 卷标:51(49) 页码:12303-12306
吗啡置于锌体系中,化学反应生成 菲
参考文献:Vongerichten,Chemische Berichte,1901,Vol. 34,P. 767,1162
标题:Vongerichten,Chemische Berichte,1901,Vol. 34,P. 767,1162
海关参考信息
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- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.
专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.
专利号:US-7652164-B2
优先权日:2005-09-13
标题:Process for the direct synthesis of trialkoxysilane
发明人：LEWIS KENRICK M; MEREIGH ABELLARD T; O'YOUNG CHI-LIN; CAMERON RUDOLPH A
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:The Direct Synthesis of trialkoxysilane is carried out by conducting the Direct Synthesis reaction of silicon and alcohol, optionally in solvent, in the presence of a catalytically effective amount of Direct Synthesis catalyst and an effective catalyst-promoting amount of Direct Synthesis catalyst promoter, said promoter being an organic or inorganic compound possessing at least one phosphorus-oxygen bond.
专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.
专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.
专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Agrawal N, Kumar V, Shahi SK. Biodegradation and detoxification of phenanthrene in in vitro and in vivo conditions by a newly isolated ligninolytic fungus Coriolopsis byrsina strain APC5 and characterization of their metabolites for environmental safety. Environ Sci Pollut Res Int. 2021 Jul 6. doi: 10.1007/s11356-021-15271-w. Epub ahead of print. 37(6):2039-2049. Chinese. doi: 10.13345/j.cjb.200752. 39(8):870-877. Chinese. doi: 10.3724/SP.J.1123.2020.09005.
106:136-146. doi: 10.1016/j.jes.2021.01.017. Epub 2021 Feb 1. 9(6):1327. doi: 10.3390/microorganisms9061327.
8: Swe HN, Sritularak B, Rojnuckarin P, Luechapudiporn R. Inhibitory Mechanisms of Lusianthridin on Human Platelet Aggregation. Int J Mol Sci. 2021 Jun 25;22(13):6846. doi: 10.3390/ijms22136846. 478(13):2517-2531. doi: 10.1042/BCJ20210244. 56(6):439-447. German. doi: 10.1055/a-1204-5169. Epub 2021 Jun 29.
合成参考文献
合成方法参考DOI号:10.1002/jhet.5570410101
📝 需求与反馈
尽可能描述清楚需求与问题信息
