CAS: 7216-42-4; 4-Formylpyridine 1-Oxide

上下游产品

pyridine-4-aldehyde diacetate pyridin-4-ylmethanediol N-oxide pyridine-4-carbaldehyde 4-methylpyridine-1-oxide hydroxy-(1-oxy-[4]pyridyl)-acetonitrile N-(4-pyridylmethylene)-t-butylamine N,N'-dioxide 4-pyridinecarboxaldehyde N-oxide phenylhydrazone 2-methyl-N-(4-pyridinylmethylene)-2-propanamine N,N'-dioxide

📜4-甲基吡啶氧化物置于selenium(Iv) Oxide体系中,用 吡啶 作为反应溶剂,化学反应 24.0H,反应生成 4-吡啶醛 N-氧化物
参考文献:Hydrogen Bonding Network Assembled With 2-Amino-3-Hydroxypyridium And Isonicotinate-N-Oxide
标题:Hydrogen Bonding Network Assembled With 2-Amino-3-Hydroxypyridium And Isonicotinate-N-Oxide
摘要:单晶 X 射线衍射分析表征了由 2-氨基-3-羟基吡啶,异烟酸-N-氧化物和晶格水组成的化合物 (C5H7N2O)-(C6H4No3)-H2O (1) 的晶体结构:单斜,P21/c,A = 9.6905(8),B = 6.0040(4),C = 21.在 1 中,去质子化的异烟酸-N-氧化物,质子化的 2-氨基-3-羟基吡啶和晶格水通过一系列经典氢键连接形成二维层.然后,这些二维薄片通过弱氢键组装成三维网络.
DOI:10.1007/s10870-007-9200-2

专利信息

专利号:US-5767131-A
优先权日:1993-04-05
标 题 :Dihydropyridines and new uses thereof
发明人：GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:The invention provides a method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the structure: ##STR1## wherein Y is --(CH 2 ) n --, where n is 1, 2, 3, 4 or 5; --(CH 2 ) h --O--(CH 2 ) k --, where h and k are independently the same or different and are 2, 3 or 4; --(CH 2 ) h --CHâ•?CH--(CH 2 ) k --; or --(CH 2 ) h --C.tbd.C--(CH 2 ) k --, where h and k are independently the same or different and are 1, 2, 3 or 4; wherein Z is O, NH, or CH 2 ; wherein R 1 is a linear or branched chain alkyl, alkoxyalkyl or arylalkyl group; wherein R 2 and R 4 are independently the same or different and are H, or a linear or branched chain alkyl group; wherein R 3 is H, a linear or branched chain alkyl, alkoxy, alkoxyalkyl or acyl group; and wherein R 5 and R 6 are independently the same or different and are H, OH, Cl, Br, F, NO 2 , CN, CF 3 , or NH 2 , or a linear or branched chain alkyl, alkoxy, alkoxycarbonyl, acyl, alkylsulfoxide, alkylsulfone, or mono- or dialkylamino group. Other active compounds containing one, two or three rings are also disclosed as well as pharmaceutical compositions prepared therefrom and methods of use in the treatment of BPH, inhibition of cholesterol synthesis, and reduction of intraocular pressue.

专利号:US-6608086-B2
优先权日:1993-04-05
标 题:Dihydropyridines and new uses thereof
发明人：GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:This invention provides dihydropyridines useful for treatment of prostatic hyperplasia, inhibition of cholesterol synthesis, and/or reduction of intraocular pressure.