CAS: 646-07-1; 4-Methylpentanoic Acid

相似化合物

25415-67-2 2412-80-8 626-89-1

上下游产品

CAS号626-89-1 4-甲基-1-戊醇 | CAS号110-53-2 1-溴戊烷 | CAS号57-57-8 丙内酯 | CAS号1068-55-9 异丙基氯化镁 | CAS号201230-82-2 carbon monoxide | CAS号541-31-1 异戊硫醇 | CAS号504-85-8 4-甲基-3-戊烯酸 | CAS号540-88-5 醋酸叔丁酯 | CAS号74965-92-7 5-isobutyl-2,2-... | CAS号503-74-2 异戊酸 | CAS号1119-29-5 Pentanamide, 4-... | CAS号38136-29-7 4-甲基戊酰氯 | CAS号5963-14-4 8-甲基壬酸 | CAS号21550-01-6 1-(4-methoxyphe... | CAS号7782-99-2 亚硫酸 | CAS号28659-87-2 (S)-2-溴-4-甲基戊酸 | CAS号2412-80-8 4-甲基戊酸甲酯 | CAS号2508-63-6 DL-Leucine, hyd... | CAS号3123-97-5 5,5-二甲基二氢呋喃-2(3H)-酮 | CAS号23327-19-7 4-hydroxy-4-met...

4-甲基-1-戊烯 反应生成 4-甲基戊酸
参考文献:Organoboranes For Synthesis. 14. Convenient Procedures For The Direct Oxidation Of Organoboranes From Terminal Alkenes To Carboxylic Acids
标题:Organoboranes For Synthesis. 14. Convenient Procedures For The Direct Oxidation Of Organoboranes From Terminal Alkenes To Carboxylic Acids
摘要:For The First Time,A Highly Efficient And Direct Oxidation Of A Variety Of Organoborane Intermediates Into Carboxylic Acids Has Been Demonstrated,Without An Increase Or Decrease Of Carbon Atoms. Synthetically Useful Procedures Have Been Developed For The Ready Conversion Of Representative Terminal Alkenes Into Carboxylic Acids Via Oxidation Of The Organoboranes Obtained By Hydroboration Of The Terminal Alkenes. The Oxidation Works Well With A Variety Of Organoboranes Derived From Reagents Such As Dibromoborane-Methyl Sulfide (Hbbr2.Sme2),Monobromoborane-Methyl Sulfide (H2Bbr.Sme2),Monochloroborane-Methyl Sulfide (H2Bcl.Sme2),Borane-Methyl Sulfide (H3B.Sme2),Thexylborane (H2Bthx),And Dicyclohexylborane (Hbchx2). The Oxidation Is Achieved In A Convenient Manner With Pyridinium Dichromate (Pdc),Sodium Dichromate In Aqueous Sulfuric Acid (Na2Cr2O7-H2So4) And Chromium Trioxide In 90% Aqueous Acetic Acid (Cro3-Hoac-H2O). These Oxidations Afford Carboxylic Acids In Very Good Yields With Complete Retention Of The Structure Of The Organic Group Attached To Boron.
DOI:10.1021/jo00049A024

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-4250330-A
优先权日:1977-04-13
标题:Process for the recovery of the solvent and of the by-produced methylacetate in the synthesis of terephthalic acid
发明人：COSTANTINI GIUSEPPE; PAOLI PIETRO; SERAFINI MAURO
权利人:MONTEDISON SPA
摘要:The invention refers to an improved process for the recovery of the solvent and of the by-produced methylacetate in the synthesis of terephthalic acid, said synthesis being usually consisting of an oxidation of paraxylene with air, in the presence of a catalyst system composed by cobalt, manganese and bromine, in a solvent consisting of acetic acid, according to the equation (1): n n C.sub.6 H.sub.4 (CH.sub.3).sub.2 +3 O.sub.2 →C.sub.6 H.sub.4 n n (COOH) 2 =2 H 2 O (1) n More particularly, the improved process of this invention comprises the oxidation of para-xylene in acetic acid solution and in the presence of a catalytic system based on manganese, bromine and cobalt, whereby water is formed and methylacetate is by-produced during the oxidation, whereby solid terephthalic acid is separated from the mother liquor and whereby one withdraws from the oxidation zone a liquid which is obtained by condensing the vapors released during the oxidation and which are mainly consisting of acetic acid and water, the improvement consisting of the fact that: n (a) the liquid obtained by condensing the released vapors and said mother liquor are fed both to an azeotropic distillation system in which the azeotropic agent is isobutyl-acetate; n (b) the light ends of the azeotropic distillation, richer in water, are condensed and demixed into two phases, wherein the aqueous phase, which is lower and contains isobutyl-acetate and methyl-acetate, is conveyed to a stripping, whereby isobutyl-acetate and methyl-acetate are recovered, and wherein the organic phase is recycled to the azeotropic distillation.

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:WO-2017175233-A1
优先权日:2016-04-04
标 题:Process for large scale liquid phase synthesis of carbetocin and its novel intermediates
发明人：Mohammed Khalid Anwer; Mohammed Mohosin Layek
权利人:DAVULURI RAMAMOHAN RAO
摘要:A process for large scale liquid phase synthesis of Carbetocin is disclosed. Novel intermediates of formula (A), formula (B), and processes for their preparation are also disclosed.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-9683007-B2
优先权日:2009-12-18
标 题 :Methods for the purification of deoxycholic acid
发明人：MORIARTY ROBERT M; PRASAD ACHAMPETA RATHAN; REID JOHN GREGORY; SWARINGEN JR ROY A
权利人:KYTHERA BIOPHARMACEUTICALS INC
摘要:Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxysteroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This inversion is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.