CAS: 60217-34-7; Lithium,Tris(3-Methylbutan-2-yl)Boranuide

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CAS号32327-52-9 tris(3-methylbu...

三(1,2-二甲基丙基)-硼烷 在 正丁基锂体系中,用 四氢呋喃,正戊烷作为反应溶剂,以>99的收率获得lithium Tri-Sec-Butyl(Hydrido)Borate
参考文献:碱金属氢化物的加成化合物:Xviii.三烷基硼烷与叔丁基锂的反应.制备三烷基硼氢化锂的通用便捷方法
标题:碱金属氢化物的加成化合物:Xviii.三烷基硼烷与叔丁基锂的反应.制备三烷基硼氢化锂的通用便捷方法
摘要:考察了叔丁基锂与具有广泛不同空间要求的代表性三烷基硼烷的反应.即使在-78°C下,该反应在醚溶剂中也迅速发生,并以定量收率形成相应的三烷基硼氢化锂.这种合成是高度通用的,甚至包含受强烈阻碍的三烷基硼烷,例如三(反-2-甲基环戊基)硼烷和三唾液酸基硼烷.唯一的副产物是异丁烯,其通常是无害的且易于除去.通过氢化物分析,红外光谱和11对三烷基硼氢化锂进行了表征b Nmr谱.三烷基硼氢化物的形成似乎是由于动力学因素,而不是由于热力学因素.该反应为三烷基硼氢化锂提供了一种高度通用,简便且定量的途径.
Doi:10.1016/S0022-328X(00)83693-1

专利信息

专利号:US-7247752-B2
优先权日:2004-10-01
标 题 :Methods for the synthesis of astaxanthin
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
权利人:CARDAX PHARMACEUTICALS INC
摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:WO-2020255049-A1
优先权日:2019-06-20
标题:Process for the preparation and identification of deuterated eugenol
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present invention provides a novel, simple, unique and viable processes for the synthesis of deuterium incorporated eugenols, such as deuterated eugenol (II), regioisomeric deuterated eugenol (III), and deuterated variant of methyl eugenol (V).

专利号:US-6268537-B1
优先权日:1999-05-25
标 题:Method of synthesis of lithium substituted borohydride reagents and method of synthesis of reactive lithium hydride
发明人：BURKHARDT ELIZABETH R; SUTTON CHRISTOPHER P; BRUENING JOERG; ROUDA DAVID F
权利人:MINE SAFETY APPLIANCES CO
摘要:A synthetic route for forming lithium trisubstituted borohydride compounds comprises the step of reacting a processed lithium hydride reactant with a trisubstituted borane wherein the reaction is maintained for a period of time in a temperature range of approximately 15° C. to approximately 42° C. A method of synthesizing LiH comprises the step of reacting an alkyl lithium (for example, n-butyl lithium) with hydrogen in the presence of tetrahydrofuran. The reaction temperature is preferably maintained in the range of approximately -78° C. to approximately 25° C.

专利号:US-6399767-B1
优先权日:1996-09-03
标 题 :Intermediates for the synthesis of vitamin D and steroid derivatives and process for preparation thereof
发明人：HORNE DAVID A; KUBODERA NOBORU; SUZUKI HIROSHI; SHIMIZU HITOSHI
权利人:UNIV COLUMBIA; CHUGAI PHARMACEUTICAL CO LTD
摘要:A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R 1 and R 2 independently is optionally substituted C 1 -C 6 alkyl; each of W and X is independently hydrogen or C 1 -C 6 alkyl; Y is O, S or NR 3 where R 3 is hydrogen, C 1 -C 6 alkyl or a protective group; and Z is a CD ring structure, a steroid structure, or a vitamin D structure, each of which optionally having structure (IV) wherein W, X, Y and Z are defined above, in the presence of a base, with a compound having structure (V) or (v′) wherein n, R 1 and R 2 are as defined above, and E is an eliminating group.

专利号:EP-0018594-B1
优先权日:1979-04-27
标题:Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
摘要:Disclosed is a stereocontrolled process for the preparation of 3-(1-hydroxyethyl) azetidinones which are useful in the synthesis of thienamycin and its analogues.