CAS: 578-51-8; 1-Bromo-2-(Chloromethyl)Benzene

该化合物是属于卤化物类的有机化合物,其第二个位置为苯基组,第二个位置为溴原子,另一个位置为苯基原子,与苯基碳相连的氯原子.该化合物一般没有颜色可粉黄,具有芳香味的特征,在乙醚和氯仿等有机溶剂中具有中度溶解性,但由于其疏水性,其溶解性有限.2-Bromobenzyl氯化物具有反应性,特别是由于存在卤化亚体,因此在各种有机合成反应中有用,包括核生殖器替代和混合反应.必须小心处理这一化合物,因为通过皮肤吸入或吸收会有害,在实验室环境中使用时应采取适当的安全措施.此外,最好将其储存在远离不相容物质的冷干的地方.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号18982-54-2 2-溴苄醇 | CAS号95-46-5 2-溴甲苯 | CAS号50-00-0 甲醛 | CAS号108-86-1 溴苯 | CAS号7791-25-5 磺酰氯 | CAS号94-36-0 过氧化苯甲酰 | CAS号7647-01-0 盐酸 | CAS号7646-78-8 四氯化锡 | CAS号209223-84-7 1-(2-bromopheny... | CAS号89-51-0 邻羧基苯乙酸 | CAS号698-19-1 N-甲基-2-溴苄胺 | CAS号724-98-1 2-苯氧基甲基苯甲酸 | CAS号31926-67-7 Thiophene,3-[(2... | CAS号15115-58-9 3-(2-溴苯基)丙酸 | CAS号15115-60-3 4-溴-1-茚酮 | CAS号113419-96-8 1-trimethylstan... | CAS号113419-95-7 2,2'-bis((trime...

合成工艺路线路线简述

    📜2-溴甲苯置于磺酰氯,过氧化苯甲酰体系中,化学反应生成 2-溴苄氯
    参考文献:A Study Of The Peroxide-Catalyzed Chlorination Of The Bromotoluenes With Sulfuryl Chloride
    标题:A Study Of The Peroxide-Catalyzed Chlorination Of The Bromotoluenes With Sulfuryl Chloride
    摘要:
    DOI:10.1021/ja01150A509

    海关参考信息

    专利信息


    专利号:US-6753347-B2
    优先权日:1999-06-28
    标题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
    发明人:KISHI NAOYUKI; NAKAMURA YOSHITAKA; ABE NARUMI; TAKEBAYASHI TOYONORI
    权利人:SANKYO CO
    摘要:This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, n wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.

    专利号:US-2003199580-A1
    优先权日:1999-06-28
    标 题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof

    专利号:EP-1326851-B1
    优先权日:2000-10-13
    标 题 :Substituted dipeptides as growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
    权利人:LILLY CO ELI
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:US-7999090-B2
    优先权日:2000-07-07
    标 题:Fungal cell wall synthesis gene
    发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
    权利人:EISAI R&D MAN CO LTD
    摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

    专利号:US-7125840-B2
    优先权日:2001-10-09
    标题:Substituted dipeptides as growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
    权利人:LILLY CO ELI
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:US-6525220-B2
    优先权日:1999-06-28
    标 题 :Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Keglevich, Gy.; Grün, A., Science of Synthesis Knowledge Updates, (2015) 2, 335.
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