📜2-溴甲苯置于磺酰氯,过氧化苯甲酰体系中,化学反应生成 2-溴苄氯 参考文献:A Study Of The Peroxide-Catalyzed Chlorination Of The Bromotoluenes With Sulfuryl Chloride 标题:A Study Of The Peroxide-Catalyzed Chlorination Of The Bromotoluenes With Sulfuryl Chloride 摘要: DOI:10.1021/ja01150A509
专利号:US-6753347-B2 优先权日:1999-06-28 标题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof 发明人:KISHI NAOYUKI; NAKAMURA YOSHITAKA; ABE NARUMI; TAKEBAYASHI TOYONORI 权利人:SANKYO CO 摘要:This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, n wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkoxyl, etc., R 2 is C 1 -C 6 alkyl, and R 3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.
专利号:US-2003199580-A1 优先权日:1999-06-28 标 题:Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof
专利号:EP-1326851-B1 优先权日:2000-10-13 标 题 :Substituted dipeptides as growth hormone secretagogues 发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF 权利人:LILLY CO ELI 摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:US-7125840-B2 优先权日:2001-10-09 标题:Substituted dipeptides as growth hormone secretagogues 发明人:DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF 权利人:LILLY CO ELI 摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
专利号:US-6525220-B2 优先权日:1999-06-28 标 题 :Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof