CAS: 57648-21-2; 1-(4-Fluorophenyl)-4-[4-(2-Sulfanylidene-3H-Benzimidazol-1-yl)Piperidin-1-Yl]Butan-1-One

上下游产品

CAS号57718-48-6 N-[1-[3-[2-(4-f... | CAS号65053-26-1 4-(2-Aminoanili... | CAS号7379-35-3 4-氯吡啶盐酸盐 | CAS号65053-27-2 4-[(2-Aminophen... | CAS号95-54-5 邻苯二胺(OPD) | CAS号3308-94-9 2-(3-氯丙基)-2-(4-...

📜4-(2-Aminoanilino)-1-<3-(4-Fluorobenzoyl)Propyl>Pyridinium Chloride Ethylene Acetal置于二硫化碳,氢氧化钾,Sodium Tetrahydroborate体系中,用 乙醇 作为反应溶剂,化学反应 5.5H,反应生成 替米哌隆
参考文献:Psychotropic Agents. Vi. An Improved Synthetic Method For 4'-Fluoro-4-(4-(2-Thioxo-1-Benzimidazolinyl)Piperidino)Butyrophenone.
标题:Psychotropic Agents. Vi. An Improved Synthetic Method For 4'-Fluoro-4-(4-(2-Thioxo-1-Benzimidazolinyl)Piperidino)Butyrophenone.
摘要:标题化合物 (8) 是通过两种改进方法制备的.首先,用芳基氯(5)处理 4-氨基吡啶(9),然后用 Nabh4 还原反应生成的 4-氨基吡啶鎓盐(10),制备 4-氨基哌啶衍生物(11).11 与 2-Chloronitrobenzene 反应反应生成中间体 (6).随后,以 4-氯吡啶 (12) 为起点,通过吡啶鎓盐 (14) 同样制备出了关键的中间体 (7).用这种方法制备的目标化合物(8)收率很高,其技术优势在于四个步骤(13->14->7->8)可以方便地在一次反应中完成.
DOI:10.1248/cpb.30.719

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-12121740-B2
优先权日:2021-01-29
标题:Wearable illumination device and system for inducing synthesis of vitamin d in the body
发明人：YOO SEUNGHYUP; PARK JAEHYEOK; MOON HANUL; KOO SUNHYOUNG; SEOK CHANGHUN; CHOI DONGHO; LEE HYUK JOO; YOON IN-YOUNG; AHN JUN SEOK; CHOI JI SU; HONG JUNG KYUNG; KIM TAE; KANG JISEUNG; JUNG JIEUN
权利人:KOREA ADVANCED INST SCI & TECH; SEOUL NAT UNIV HOSPITAL; GWANGJU INST SCIENCE & TECH
摘要:A system for inducing synthesis of Vitamin D in a body includes a wearable illumination device formed in a structure that is wearable on the body, and including a plurality of light sources configured to radiate an ultraviolet light to a skin of a worn part; and a control device connected to the plurality of light sources and configured to drive the plurality of light sources to radiate the ultraviolet light, wherein the wearable illumination device includes a light diffusion panel configured to equalize an irradiance of the ultraviolet light reaching the skin by causing diffusion of the ultraviolet light radiated from the plurality of light sources.

专利号:US-7300639-B2
优先权日:2002-12-03
标 题:Process for removing metals from liquids
发明人：LIU WANSHENG
权利人:BRISTOL MYERS SQUIBB CO
摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:EP-1953140-A1
优先权日:2007-01-24
标 题 :Process for the preparation of ezetimibe and derivatives thereof
发明人：STIMAC ANTON; MOHAR BARBARA; STEPHAN MICHEL; BEVC MOJCA; ZUPET ROK; GARTNER ANDREJ; KROSELJ VESNA; SMRKOLJ MATEJ
权利人:KRKA
摘要:The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well.

专利号:KR-20220110120-A
优先权日:2021-01-29
标 题:Wearable illumination device and system for inducing synthesis of vitamin d in the body