CAS: 566190-45-2; 2-Trimethylsilylethyl 4-Diphenylphosphanylbenzoate

上下游产品

4-二苯基膦苯甲酸 4-Diphenylphosphanobenzoic Acid 2129-31-9

📜2-(Trimethylsilyl)Ethyl 4-(Diphenylphosphoryl)Benzoate置于甲基二乙氧基硅烷,双(对硝基苯基)磷酸酯体系中,用 甲苯 作为反应溶剂,以73%的收率获得产物4-二苯基膦基苯甲酸 2-(三甲基硅基)乙酯
参考文献:Highly Chemoselective Metal-Free Reduction Of Phosphine Oxides To Phosphines
标题:Highly Chemoselective Metal-Free Reduction Of Phosphine Oxides To Phosphines
摘要:Unprecedented Chemoselective Reductions Of Phosphine Oxides To Phosphines Proceed Smoothly In The Presence Of Catalytic Amounts Of Specific Bronsted Acids. By Utilizing Inexpensive Silanes,E.G.,Pmhs Or (Eto)(2)Mesih,Other Reducible Functional Groups Such As Ketones,Aldehydes,Olefins,Nitriles,And Esters Are Well-Tolerated Under Optimized Conditions.
DOI:10.1021/ja3069165

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.