CAS: 5076-82-4; 1,4-Dimethylpiperazine-2,5-Dione

该化合物是碳氢化合物(N-甲基甘油)的循环衍生物,其特点是五人环状环状结构,该化合物主要用作有机合成的多种中间体,特别是在结和热循环化学中,其氢化物形式可增强反应性,在温和条件下促进有效的相互碰撞反应,关键优点包括高纯度,受控储存下的稳定性和与一系列溶剂和试剂的兼容性.

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5625-52-5 3027-05-2 106-57-0

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合成工艺路线路线简述

    📜N-甲基-2-羟基乙胺置于ru(H)(Cl)(Pnnh(T-Butyl))(Co),Potassium Tert-Butylate体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 24.0H,以99%的收率获得产物肌氨酸酐
    参考文献:Ruthenium Complexes And Their Uses As Catalysts In Processes For Formation And/or Hydrogenation Of Esters,Amides And Related Reactions
    标题:Ruthenium Complexes And Their Uses As Catalysts In Processes For Formation And/or Hydrogenation Of Esters,Amides And Related Reactions
    摘要:本发明涉及新型a1-A4式钌配合物及其用途,包括(1)醇的脱氢偶联制备酯;(2)酯的加氢制备醇(包括环酯(内酯)或环二酯(二内酯)的加氢,或聚酯的加氢);(3)从醇和胺制备酰胺(包括通过二醇和二胺反应或氨基醇的聚合形成聚酰胺(例如,多肽),或从p-氨基醇形成环二肽);(4)酰胺的加氢(包括环二肽,多肽和聚酰胺的加氢至醇和胺);(5)有机碳酸酯(包括聚碳酸酯)的加氢至醇或羰基酸酯(包括聚羰基酸酯)或脲衍生物的加氢至醇和胺;(6)次级醇的脱氢至酮;(7)酯的酰胺化(即通过酯和胺合成酰胺);(8)使用酯对醇进行酰化;(9)醇与水和碱的偶联形成羧酸;以及(10)通过氨基醇与水和碱的偶联制备氨基酸或其盐.本发明还涉及使用某些已知的钌配合物从氨基醇制备氨基酸或其盐.

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    专利信息


    专利号:WO-2024126857-A1
    优先权日:2022-12-16
    标题 :Synthesis of poly(amino acids)
    发明人：THORNTON PAUL D; WALL PATRICK A
    权利人:UNIV LEEDS INNOVATIONS LTD
    摘要:The present invention contemplates the formation of poly(amino acids) via a 2,5-diketopiperazine intermediate. The 2,5-diketopiperazine undergoes a ring-opening polymerisation reaction to afford the corresponding poly(amino acid).

    专利号:CN-115536598-B
    优先权日:2022-09-15
    标 题 :A new method for the synthesis of 1,4-dimethyl-2,5-piperazinedione compounds

    专利号:CN-115536598-A
    优先权日:2022-09-15
    标题 :A new method for the synthesis of 1,4-dimethyl-2,5-piperazine diketones

    专利号:US-2015284349-A1
    优先权日:2013-12-20
    标 题:Epidithiodiketopiperazine compounds, compositions, and methods
    发明人：BALAN CHENERA; MAHAJAN SUMIT; NAGAVARAPU USHA; GUPTA SHALABH
    权利人:GLOBAVIR BIOSCIENCES INC
    摘要:Epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of their synthesis, as part of treating, inhibiting and reducing transcription and translation of hypoxia inducible genes are described.

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    合成参考文献


    参考文献:10.1007/978-3-642-49879-4_6
    参考文献:10.1007/3-540-30592-0_3
    摘要:Free-Radical-Induced DNA Damage and Its Repair. The Hydroxyl Radical. 2006.
    参考文献:10.1055/s-0039-1690614
    摘要:Nocera G, Murphy JA. Ground State Cross-Coupling of Haloarenes with Arenes Initiated by Organic Electron Donors, Formed in situ: An Overview. Synthesis. 2019 Sep 13;52(03):327–36. doi: 10.1055/s-0039-1690614.
    参考文献:10.1002/ejoc.200800605
    摘要:Jainta M, Nieger M, Bräse S. Microwave‐Assisted Stereoselective One‐Pot Synthesis of Symmetrical and Unsymmetrical 2,5‐Diketopiperazines from Unprotected Amino Acids. Eur J Org Chem. 2008 Oct 23;2008(32):5418–24. doi: 10.1002/ejoc.200800605.
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