CAS: 4645-11-8; 2-Bromo-6-Ethoxypyridine

该化合物是一种有机化合物,其特征是其环,即六人组成的含有一个氮原子的芳香热循环,二点方位的溴原子和六点的乙氧组,其独特的化学特性是该化合物的特性.该化合物一般是无色的,黄色液体或固体,取决于其纯度和形态.它溶于乙醇和二氯甲烷等有机溶剂,但由于乙醇组的疏水性,其溶液在水中的溶解性有限. 2-Bromo-6-乙氧基丙烯可参与各种化学反应,包括核循环替代和混合反应,使其在合成有机化学中具有价值,特别是在制药和农用化学的开发中.此外,其溴基成分可成为进一步功能化的灵活处理器.与许多卤化化合物一样,必须谨慎处理这一物质,同时考虑到潜在的毒性和环境影响.

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合成工艺路线路线简述

    📜2,6-二溴吡啶置于sodium Ethanolate,Sodium体系中,用 乙醇,乙酸乙酯,甲苯,正戊烷 作为反应溶剂,化学反应生成 2-溴-6-乙氧基吡啶
    参考文献:Composition For The Treatment Of Damaged Tissue
    标题:Composition For The Treatment Of Damaged Tissue
    摘要:描述了一种用于受损组织,如伤口治疗(例如愈合)的药物.该药物包括包含以下成分的组合物:(a)生长因子;和(b)抑制剂;以及可选的(c)药用载体,稀释剂或赋形剂;其中抑制剂可以抑制至少一种在受损组织,如伤口环境中上调的特定不良蛋白质(例如特定蛋白酶)的作用.

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    专利信息


    专利号:US-7884125-B2
    优先权日:2008-04-30
    标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
    发明人:STEVENS CHRISTIAN; HEUGEBAERT THOMAS
    权利人:UNIV GENT
    摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

    专利号:US-2009275616-A1
    优先权日:2008-04-30
    标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

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