CAS: 440-17-5; 1-Methyl-4-(3-(2-(Trifluoromethyl)-10H-Phenothiazin-10-yl)Propyl)Piperazine-1,4-Diium Chloride

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CAS号1549-88-8 trifluoperazine...

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    专利号:US-9486471-B2
    优先权日:2012-03-28
    标题:Combination therapy for the treatment of cancer
    发明人：BHATIA MICKIE; SACHLOS ELEFTHERIOS
    权利人:UNIV MCMASTER
    摘要:Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

    专利号:CN-113845450-B
    优先权日:2020-06-28
    标题 :Synthesis method of mesotrione and homologs thereof

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    主要参考文献


    1: Bryan EJ, Purcell MA, Kumar A. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11:CD005474. doi: 10.1002/14651858.CD005474.pub2. Review. Epub 2016 Aug 24. Review. doi: 10.1007/s40263-015-0282-7. Review. doi: 10.2436/20.1501.01.229. Review. doi: 10.1002/14651858.CD009831.pub2. Review. doi: 10.14423/SMJ.0000000000000190. Review. doi: 10.1002/14651858.CD009396.pub2. Review. doi: 10.1002/14651858.CD010226.pub2. Review. doi: 10.3390/ijms141122558. Review.
    10: Berchtold MW, Villalobo A. The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer. Biochim Biophys Acta. 2014 Feb;1843(2):398-435. doi: 10.1016/j.bbamcr.2013.10.021. Epub 2013 Nov 2. Review. Review. pii: 1002. Review.
    13: Bola J, Kao D, Soydan H. Antipsychotic medication for early episode schizophrenia. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD006374. doi: 10.1002/14651858.CD006374.pub2. Review.

    合成参考文献


    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 122(129), 1959 []
    摘要:Acta Pharmacologica et Toxicologica., 19(87), 1962 []
    摘要:Schafer, E.W. 1972. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicology and Applied Pharmacology. 21:315-330.
    摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382.
    摘要:Schafer, E.W. Jr. and D.J. Cummings. 1972. An evaluation of 148 compounds as avian immobilizing agents. U.S. Fish and Wildlife Service, Special Scientific Report-Wildlife No.150. 30pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/E_SchaferCunningham72.pdf
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