CAS: 385-01-3; 3-Fluoro-2-Nitrophenol

该化合物是一种氟化硝酸酚衍生物,可应用于有机合成和制药中间体,其主要结构特征包括三点方位的氟替代物和二点方位的硝化物组,这增强了其在电益和核球替代反应中的再活动性.该化合物因其在合成更复杂的氟芳烃化合物,农用化学品和活性药物成分(API)方面的作用而备受重视.电镀组(氟和硝)的存在会影响其酸性和溶性,使其在精细的化学过程中有用.该化合物通常因其潜在的再活动而在受控制的条件下处理.

英文名称3-Fluoro-2-Nitrophenol
中文名称2-硝基-3-氟苯酚
IUPAC名称3-fluoro-2-nitrophenol
其它别名3-氟-2-硝基苯酚; 2-Nitro-3-Fluorophenol
CAS编号385-01-3
MFCD编号:MFCD07368753
EINECS号:675-091-9
分子式:C6H4FNO3
分子量:157.1
产品CID: 1397298
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;
InChIKey: GAWNBKUTBVLIPL-UHFFFAOYSA-N
InChI=1S/C6H4FNO3/c7-4-2-1-3-5(9)6(4)8(10)11/h1-3,9H…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
防范说明P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
危险等级9
UN编号3077.0
危险品标志Xi,C
包装等级Ⅲ
安全声明36/37/39-45
危险类别码34

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 3-Fluoro-2-Nitrophenol 主要起始原料 2,6-Difluoronitrobenzene
(文献来源)合成步骤主要原料 2,6-Difluoronitrobenzene

3-氟苯酚置于硫酸体系中,化学反应生成2-硝基-3-氟苯酚
参考文献:Hodgson; Nixon,Journal Of The Chemical Society,1928,P. 1881
标题:Hodgson; Nixon,Journal Of The Chemical Society,1928,P. 1881

海关参考信息

2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
2905199090-其他饱和一元醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2011106986-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.

专利号:US-2012328569-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-8372380-B2
优先权日:2007-03-30
标题:In vivo imaging of sulfotransferases
发明人：BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
权利人:UNIV CALIFORNIA; BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
摘要:Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18 F, 123 I, 124 I, 125 I, or 11 C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.