CAS: 29289-13-2; 2-Iodo-4-Methylaniline

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CAS号106-49-0 对甲苯胺 | CAS号142-71-2 醋酸铜 | CAS号64-19-7 冰醋酸 | CAS号104-94-9 对甲氧基苯胺 | CAS号784183-53-5 2,2,2-trifluoro... | CAS号100377-05-7 2-iodo-5,5-dime... | CAS号67-56-1 甲醇 | CAS号7553-56-2 碘 | CAS号122099-10-9 1-azido-2-iodo-... | CAS号7647-01-0 盐酸 | CAS号39576-82-4 2,4-二氯-6-甲基喹唑啉 | CAS号205756-35-0 1-(2-氨基-5-甲基苯基)... | CAS号180624-14-0 4-methyl-2-(2-t... | CAS号190071-24-0 4-乙酰氨基-3-碘苯甲酸 | CAS号215589-37-0 2-炔基-4-甲基苯胺 | CAS号212063-20-2 benzyl N-(2-iod... | CAS号28566-10-1 6-methyl-4-oxo-... | CAS号2401-22-1 4-氯-3-碘甲苯 | CAS号5925-93-9 2-氨基-5-甲基苯腈 | CAS号618-76-8 4-羟基-3,5-二碘苯甲酸

4-甲基苯胺盐酸盐置于硫酸,双氧水,Potassium Iodide体系中,用 甲醇,水 用作溶剂,以43%的收率获得3-碘-4-甲基苯胺
参考文献:从苯并呋喃到吲哚:钯催化的还原性开环和通过β-酚盐消除的闭合
标题:从苯并呋喃到吲哚:钯催化的还原性开环和通过β-酚盐消除的闭合
摘要:苯并呋喃可以通过钯催化的过程进行开环,从而导致c-O键断裂.在整个还原过程中,苯并呋喃拴系的2-碘苯胺可合成有趣的2-(3-吲哚基甲基)苯酚.机理研究表明,这种不寻常的反应通过苯并呋喃的碳钯反应生成的,这是一种3-Palladed的2,3-二氢苯并呋喃中间体,然后通过苯氧根β的不常见反式消除作用而分裂成金属.在此转化过程中,N,N-二异丙基乙胺(dipea)充当碱和还原剂:它从钯(II)再生钯(0),从而实现催化转化.
Doi:10.1002/adsc.201801225

专利信息

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:CN-107915693-A
优先权日:2017-12-07
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专利号:CN-106866543-B
优先权日:2017-04-16
标 题 :A kind of method for catalyzing synthesis of benzimidazole compound under microwave irradiation in aqueous phase

专利号:CN-106866543-A
优先权日:2017-04-16
标题:A kind of method that catalyzes the synthesis of benzimidazole compound under microwave irradiation in aqueous phase

专利号:CN-107428688-B
优先权日:2015-04-06
标题:Efficient synthesis of carbazole derivatives

专利号:US-2007123711-A1
优先权日:2004-01-28
标 题:Synthesis methods and intermediates for the manufacture of rizatriptan